Inverse probability of treatment weighting (IPTW) is a popular method for estimating the average treatment effect (ATE). However, empirical studies show that the IPTW estimators can be sensitive to the misspecification of the propensity score model. To address this problem, researchers have proposed to estimate propensity score by directly optimizing the balance of pretreatment covariates. While these methods appear to empirically perform well, little is known about how the choice of balancing conditions affects their theoretical properties. To fill this gap, we first characterize the asymptotic bias and efficiency of the IPTW estimator based on the covariate balancing propensity score (CBPS) methodology under local model misspecification. Based on this analysis, we show how to optimally choose the covariate balancing functions and propose an optimal CBPS-based IPTW estimator. This estimator is doubly robust; it is consistent for the ATE if either the propensity score model or the outcome model is correct. In addition, the proposed estimator is locally semiparametric efficient when both models are correctly specified. To further relax the parametric assumptions, we extend our method by using a sieve estimation approach. We show that the resulting estimator is globally efficient under a set of much weaker assumptions and has a smaller asymptotic bias than the existing estimators. Finally, we evaluate the finite sample performance of the proposed estimators via simulation and empirical studies. An open-source software package is available for implementing the proposed methods.
机构:
Johnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USAJohnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USA
Wallace, Stuart R.
Singh, Sachinkumar B.
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Johnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USAJohnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USA
Singh, Sachinkumar B.
Blakney, Rebekah
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Johnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USAJohnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USA
Blakney, Rebekah
Rene, Lexi
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Johnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USAJohnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USA
Rene, Lexi
Johnston, Stephen S.
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Johnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USAJohnson & Johnson, MedTech Epidemiol & Real World Data Sci, New Brunswick, NJ 08933 USA
机构:
BioCruces Health Research Institute, Spain
Clinical Epidemiology Unit-Cruces University Hospital, SpainDepartment of Applied Mathematics, Statistics and Operational Research, University of the Basque Country (UPV/EHU), Spain
Martinez-Indart, Lorea
Pijoán, JoséIgnacio
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BioCruces Health Research Institute, Spain
Clinical Epidemiology Unit-Cruces University Hospital, Spain
Network Biomedical Research Centre for Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, SpainDepartment of Applied Mathematics, Statistics and Operational Research, University of the Basque Country (UPV/EHU), Spain
机构:
Ohio State Univ, Ctr Biostat, Columbus, OH 43221 USA
Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USAOhio State Univ, Ctr Biostat, Columbus, OH 43221 USA
Hade, Erinn M.
Lu, Bo
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Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USAOhio State Univ, Ctr Biostat, Columbus, OH 43221 USA