Synthesis and NMR characterization of monomethoxypoly(ethylene glycol) aldehydes from monomethoxypoly(ethylene glycol) tosylates

被引：3
|
作者：
Ladd, DL [1 ]
Henrichs, PM [1 ]
机构：
[1] Nycomed Amersham Imaging, Wayne, PA USA
来源：
SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 22期
关键词：
D O I：
10.1080/00397919809458693
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A procedure for the synthesis of monomethoxypoly(ethylene glycol) aldehydes from monomethoxypoly(ethylene glycol) tosylates is described. The tosylates are converted to aldehydes in high yield via treatment with disodium hydrogen phosphate and DMSO; minimal oligomeric by-products are formed.
引用
收藏
页码：4143 / 4149
页数：7
相关论文
共 50 条
  • [21] SYNTHESES OF 5-FLUOROURACIL-TERMINATED MONOMETHOXYPOLY(ETHYLENE GLYCOL)S, THEIR HYDROLYSIS BEHAVIOR, AND THEIR ANTITUMOR ACTIVITIES
    OUCHI, T
    YUYAMA, H
    VOGL, O
    JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, 1987, A24 (09): : 1011 - 1032
  • [22] HPLC method validation studies on a specific assay for monomethoxypoly(ethylene glycol) succinimido carbonate (mPEG-SC)
    van Arnum, Susan D.
    Niemczyk, Henry J.
    Chang, Chinfong
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 50 (02) : 138 - 143
  • [23] A Practical Synthesis of Nε-Monomethoxypoly(ethylene glycol)carbonyl-L-lysine Hydrochloride: A Precursor to Chiral and Mixed Branched Pegylated Reagents
    Van Arnum, Susan D.
    Niemczyk, Henry J.
    MACROMOLECULES, 2009, 42 (04) : 908 - 912
  • [24] Immunosafety and chronic toxicity evaluation of monomethoxypoly(ethylene glycol)-b-poly(lactic acid) polymer micelles for paclitaxel delivery
    Li, Chang
    Shen, Yan
    Sun, Chunmeng
    Cheraga, Nihad
    Tu, Jiasheng
    DRUG DELIVERY, 2016, 23 (03) : 888 - 895
  • [25] LIGAND RECEPTOR INTERACTIONS IN AFFINITY CELL PARTITIONING - STUDIES WITH TRANSFERRIN COVALENTLY LINKED TO MONOMETHOXYPOLY(ETHYLENE GLYCOL) AND RAT RETICULOCYTES
    DELGADO, C
    SANCHO, P
    MENDIETA, J
    LUQUE, J
    JOURNAL OF CHROMATOGRAPHY, 1992, 594 (1-2): : 97 - 103
  • [26] Synthesis of spirosilicates directly from silica and ethylene glycol/ethylene glycol derivatives
    Jitchum, V
    Chivin, S
    Wongkasemjit, S
    Ishida, H
    TETRAHEDRON, 2001, 57 (18) : 3997 - 4003
  • [27] Synthesis and Characterization of Ethylene Glycol Ester from Spent Bleaching Earth Oil and Ethylene Glycol as Hydraulic Lubricants
    Sukirno
    Farhandika, Luki
    4TH INTERNATIONAL TROPICAL RENEWABLE ENERGY CONFERENCE (I-TREC 2019), 2020, 2255
  • [28] Critical Insight into Mechanochemical and Thermal Degradation of Imidazolium-Based Ionic Liquids with Alkyl and Monomethoxypoly(ethylene glycol) Side Chains
    Mahrova, Maria
    Conte, Marcello
    Roman, Elisa
    Nevshupa, Roman
    JOURNAL OF PHYSICAL CHEMISTRY C, 2014, 118 (39): : 22544 - 22552
  • [29] The synthesis of ethylene glycol from formaldehyde
    Korneeva, G.A.
    Loktev, S.Μ.
    Russian Chemical Reviews, 1989, 58 (01) : 73 - 83
  • [30] SYNTHESIS AND CHARACTERIZATION OF POLY(ETHYLENE GLYCOL) DERIVATIVES
    HARRIS, JM
    STRUCK, EC
    CASE, MG
    PALEY, MS
    VANALSTINE, JM
    BROOKS, DE
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1984, 22 (02) : 341 - 352
12345