Molecular Profiling of Follicular Variant of Papillary Thyroid Cancer

被引：2

作者：

Spirina, L., V ^{[1
,2
]}

Chizhevskaya, S. Yu ^{[1
]}

Kondakova, I., V ^{[1
]}

机构：

[1] Tomsk Natl Res Med Ctr, Canc Res Inst, Tomsk, Russia

[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 01期

关键词：

follicular variant of papillary thyroid cancer; transcriptional factors; growth factors; AKT; m-TOR signaling path; BRAF;

D O I：

10.1007/s10517-020-04830-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The molecular features of the follicular variant of papillary thyroid cancer are closely related to the clinical behavior of the tumor and the prognosis of the disease. BRAF-V600E mutations in patients with a follicular variant of papillary thyroid cancer have not been identified; however, the majority of patients had T3-4N0M0 stage of the disease. Changes in the expression of transcription and growth factors and AKT/m-TOR signaling pathway components were detected. In addition, hyperexpression of m-TOR and 4EBP1 kinases and CAIX enzyme was shown compared to the classical variant of papillary thyroid cancer, where an increase in the nuclear factor NF-kappa B p65 and c-RAF kinase expression was observed.

引用

页码：85 / 88

页数：4

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