Epigenetic reprogramming: is deamination key to active DNA demethylation?

被引：42

作者：

Teperek-Tkacz, Marta ^{[1
,2
]}

Pasque, Vincent ^{[1
,2
]}

Gentsch, George ^{[3
]}

Ferguson-Smith, Anne C. ^{[4
]}

机构：

[1] Wellcome Trust Res Labs, Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England

[2] Univ Cambridge, Dept Zool, Cambridge CB2 2EJ, England

[3] Natl Inst Med Res, MRC, Div Syst Biol, London NW7 1AA, England

[4] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

来源：

REPRODUCTION | 2011年 / 142卷 / 05期

基金：

英国惠康基金;

关键词：

SINGLE-STRANDED-DNA; BASE EXCISION-REPAIR; CLASS-SWITCH RECOMBINATION; RNA-POLYMERASE-II; ACTIVATION-INDUCED DEAMINASE; ZYGOTIC PATERNAL GENOME; PRIMORDIAL GERM-CELLS; CYTIDINE DEAMINASE; MAMMALIAN DNA; CRYSTAL-STRUCTURE;

D O I：

10.1530/REP-11-0148

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA demethylation processes are important for reproduction, being central in epigenetic reprogramming during embryonic and germ cell development. While the enzymes methylating DNA have been known for many years, identification of factors capable of mediating active DNA demethylation has been challenging. Recent findings suggest that cytidine deaminases may be key players in active DNA demethylation. One of the most investigated candidates is activation-induced cytidine deaminase (AID), best known for its role in generating secondary antibody diversity in B cells. We evaluate evidence for cytidine deaminases in DNA demethylation pathways in vertebrates and discuss possible models for their targeting and activity regulation. These findings are also considered along with alternative demethylation pathways involving hydroxymethylation. Reproduction (2011) 142 621-632

引用

页码：621 / 632

页数：12

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