Synthesis of the Tetracyclic Framework of Polycyclic Spiro Lignan Natural Products

被引：3
|
作者：
Ali, Ghada [2 ]
Cuny, Gregory D. [1 ]
机构：
[1] Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA
[2] Univ Houston, Coll Nat Sci & Math, Dept Chem, Houston, TX 77204 USA
来源：
ACS OMEGA | 2020年 / 5卷 / 15期
关键词：
KINETIC RESOLUTION; DERIVATIVES; 5-HT2B; ACID;
D O I：
10.1021/acsomega.0c00976
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polycyclic spiro lignans are a new family of lignan natural products recently isolated from Gymnotheca involucrata. The first synthesis of two model substrates of this rare family of natural products was achieved in six steps. An efficient strategy that features Suzuki coupling and Friedel-Crafts acylation was employed to construct the ABC tricyclic fluorene framework. Subsequently, Grignard reaction followed by acid-mediated cyclization furnished the spiro cyclic ether ring D.
引用
收藏
页码：9007 / 9012
页数：6
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