Dysregulated exocytosis of angiopoietin-2 drives cerebral cavernous malformation

被引：5
|
作者：
Zhao, Helong [1 ]
Mleynek, Tara M. [1 ]
Li, Dean Y. [2 ]
机构：
[1] Univ Utah, Sch Med, Program Mol Med, Salt Lake City, UT USA
[2] Univ Utah, Sch Med & Hlth Sci, Salt Lake City, UT 84112 USA
来源：
NATURE MEDICINE | 2016年 / 22卷 / 09期
关键词：
D O I：
10.1038/nm.4178
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new study has proposed a mechanism for the pathogenesis of cerebral cavernous malformation (CCM) that links endothelial CCM3 deficiency to increased secretion of the vascular destabilizing protein angiopoietin-2 (ANGPT2).
引用
收藏
页码：971 / 973
页数：4
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