Bhimamycin A∼E and bhimanone:: Isolation, structure elucidation and biological activity of novel quinone antibiotics from a terrestrial streptomycete

被引：53

作者：

Fotso, S

Maskey, RP

Grün-Wollny, I

Schulz, KP

Munk, M

Laatsch, H

机构：

[1] Univ Gottingen, Dept Organ Chem, D-37077 Gottingen, Germany

[2] BioLeads GMBH, D-69123 Heidelberg, Germany

[3] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85281 USA

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 11期

关键词：

D O I：

10.7164/antibiotics.56.931

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

From the ethyl acetate extract of a terrestrial Streptomycete isolate, five new quinone antibiotics, bhimamycin A (2a), B (2b), C (3c), D (5a), E (7) and the new tetralone bhimanone (8) were isolated together with the known microbial products chrysophanol (1a), aloesaponarin II (1b), 3,8-dihydroxy-1-methylanthraquinone-2-carboxylic acid (1c), adenosine, 2'-deoxyadenosine, phenylacetamide, and 2-(p-hydroxyphenyl)ethanol. The structures of these natural products were deduced from the spectral data and confirmed by comparison with related compounds from the literature and by synthesis.

引用

页码：931 / 941

页数：11

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