Synthesis of the first chiral PNA monomer labelled with a Fischer-type carbene complex

被引：19
|
作者：
Maiorana, S
Licandro, E
Perdicchia, D
Baldoli, C
Vandoni, B
Giannini, C
Salmain, M
机构：
[1] Univ Milan, Ctr Eccellanza CISI, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] CNR, Ist Sci & Tecnol Mol, I-20133 Milan, Italy
[3] Ecole Natl Super Chim Paris, Lab Chim & Biochim Complexes Mol, F-75231 Paris, France
来源：
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2003年 / 204卷
关键词：
peptide nucleic acids; Fischer carbene complexes; cross-metathesis; biorganometallics;
D O I：
10.1016/S1381-1169(03)00296-6
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The synthesis, through a cross-metathesis reaction, of the first chiral peptide nucleic acid (PNA) monomer labelled with a Fischer-type carbene complex of chromium is reported. IR analysis of the new bioconjugate shows that the Cr(CO)(4) moiety represents a suitable spectroscopic probe for diagnostic purposes. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：165 / 175
页数：11
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