Treatment Efficacy of Combined Sertraline and Guanfacine in Comorbid Obsessive-Compulsive Disorder and Attention Deficit/Hyperactivity Disorder: Two Case Studies

被引：3
|
作者：
Taormina, Shibany P. [1 ,2 ]
Galloway, Matthew P. [1 ,3 ]
Rosenberg, David R. [1 ,2 ]
机构：
[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Tolan Pk Suite 5A,3901 Chrysler Serv Dr, Detroit, MI 48201 USA
[2] Childrens Hosp Michigan, Dept Psychiat, Detroit, MI 48201 USA
[3] Wayne State Univ, Sch Med, Dept Anesthesiol, Detroit, MI USA
来源：
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS | 2016年 / 37卷 / 06期
基金：
美国国家卫生研究院;
关键词：
OCD; ADHD; CBT; guanfacine; pediatric; DEFICIT HYPERACTIVITY DISORDER; MAGNETIC-RESONANCE-SPECTROSCOPY; SYMPTOM SEVERITY; CHILDREN; ADOLESCENTS; PREVALENCE; ABNORMALITIES; GLUTAMATE; BIPOLAR; OCD;
D O I：
10.1097/DBP.0000000000000290
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Objective: Treatment of obsessive-compulsive disorder (OCD) is complicated by comorbid psychiatric disorders. Successful treatment of 2 pediatric patients with severe OCD and comorbid attention deficit/hyperactivity disorder (ADHD) is described. Method: A report on 2 pediatric clinical cases (Ages 9 and 10) with comorbid OCD and ADHD was used to describe response to medication management through the serotonin transporter inhibitor, sertraline, and the noradrenergic alpha(2A) receptor agonist, guanfacine, along with cognitive behavioral therapy. Results: Cognitive behavioral therapy combined with titrated doses of the serotonin transporter inhibitor, sertraline, and the noradrenergic alpha(2A) receptor agonist, guanfacine resolved OCD symptoms and the underlying ADHD. Conclusion: The novel observations support a focused psychological and pharmacological approach to successful treatment of complex symptoms in patients with comorbid OCD and ADHD. Limitations to generalizability are discussed.
引用
收藏
页码：491 / 495
页数：5
相关论文
共 50 条
  • [21] Co-Morbid Obsessive-Compulsive Disorder and Attention Deficit Hyperactivity Disorder: Neurobiological Commonalities and Treatment Implications
    Cabarkapa, Sonja
    King, Joel A.
    Dowling, Nathan
    Ng, Chee H.
    FRONTIERS IN PSYCHIATRY, 2019, 10
  • [22] Comorbidity of obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents
    Masi, G
    Millepiedi, S
    Mucci, M
    Bertini, N
    Kanner, C
    Arcangeli, F
    COMPREHENSIVE PSYCHIATRY, 2006, 47 (01) : 42 - 47
  • [23] Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: Fact or artifact?
    Geller, DA
    Biederman, J
    Faraone, SV
    Cradock, K
    Hagermoser, L
    Zaman, N
    Frazier, JA
    Coffey, BJ
    Spencer, TJ
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2002, 41 (01): : 52 - 58
  • [24] Impact of Attention-Deficit/Hyperactivity Disorder Comorbidity on Phenomenology and Treatment Outcomes of Pediatric Obsessive-Compulsive Disorder
    Efe, Ayseguel
    Kaba, Duygu
    Canli, Merve
    Temeltuerk, Rahime Duygu
    JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2022, 32 (06) : 337 - 348
  • [25] Intractable obsessive-compulsive disorder: Comorbidity with unrecognized adult attention-deficit hyperactivity disorder?
    van der Feltz-Cornelis, CM
    JOURNAL OF NERVOUS AND MENTAL DISEASE, 1999, 187 (04) : 243 - 245
  • [26] Adult attention deficit and hyperactivity disorder comorbidity in obsessive compulsive disorder
    Bakim, Bahadir
    Ertekin, Hulya
    Ertekin, Yusuf
    Karamustafalioglu, Oguz
    INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2012, 16 : 25 - 25
  • [27] Tic Severity and Treatment in Children: The Effect of Comorbid Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Behaviors
    Tamara Pringsheim
    Child Psychiatry & Human Development, 2017, 48 : 960 - 966
  • [28] Tic Severity and Treatment in Children: The Effect of Comorbid Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Behaviors
    Pringsheim, Tamara
    CHILD PSYCHIATRY & HUMAN DEVELOPMENT, 2017, 48 (06) : 960 - 966
  • [29] Tic severity and treatment in children: the effect of comorbid attention deficit hyperactivity disorder and obsessive compulsive behaviours
    Pringsheim, T.
    MOVEMENT DISORDERS, 2017, 32
  • [30] Efficacy of sertraline in the long-term treatment of obsessive-compulsive disorder
    Koran, LM
    Hackett, E
    Rubin, A
    Wolkow, R
    Robinson, D
    AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (01): : 88 - 95
12345