Microwave-assisted One-pot Synthesis of [1,2,3]Triazolo[4′,5′:4,5] Pyrano[2,3-d] pyrimidines and their Biological Evaluation

被引：0

作者：

Venkatesh, Egurapu ^{[1
]}

Narsimha, Sirassu ^{[2
]}

Reddy, Nagavelli Vasudeva ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal, Telangana, India

[2] Chaitanya Deemed Univ, Dept Chem, Warangal, Telangana, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 01期

关键词：

Pyrimidine; 1,2,3-Triazole; Microwave irradiation; Antibacterial; Antioxidant activity; CLICK CHEMISTRY; IN-VITRO; DESIGN; 1,2,3-TRIAZOLES; ANTIBACTERIAL; DERIVATIVES; HYBRIDS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of [1,2,3]triazolo[4',5':4,5]pyrano[2,3-d]pyrimidine derivatives (4a-4j) was synthesized in eco-friendly click followed by C-C bond coupling protocol under highly efficient microwave conditions. All the synthesized compounds were characterized by spectral and analytical studies. The synthesized compounds were further evaluated for their antibacterial and antioxidant activities. Compounds 4h and 4j exhibited potent antibacterial activity against tested Gram-positive bacterial strains, and compounds 4j approximate to 1.62 fold more potent and 4h approximate to 1.08 fold more potent antioxidant activity when compared with the standard trolox.

引用

页码：125 / 130

页数：6

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