The design of efficient and selective routes to pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes

被引：15

作者：

Brooks, Gerald ^{[2
]}

Dabbs, Steven ^{[1
]}

Davies, David T. ^{[2
]}

Hennessy, Alan J. ^{[1
]}

Jones, Graham E. ^{[2
]}

Markwell, Roger E. ^{[2
]}

Miles, Timothy J. ^{[1
]}

Owston, Nathan A. ^{[2
]}

Pearson, Neil D. ^{[3
]}

Peng, Tony W. ^{[3
]}

机构：

[1] GlaxoSmithKline Inc, Infect Dis CEDD, Antibacterial Discovery Performance Unit, Stevenage SG1 2NY, Herts, England

[2] GlaxoSmithKline Inc, Infect Dis CEDD, Antibacterial Discovery Performance Unit, Harlow CM19 5AW, Essex, England

[3] GlaxoSmithKline Inc, Infect Dis CEDD, Antibacterial Discovery Performance Unit, Collegeville, PA 19426 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 38期

关键词：

D O I：

10.1016/j.tetlet.2010.07.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This Letter describes the synthesis of challenging pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes. The six different routes described are high yielding, contain no major purification issues and have been used to give gram quantities of each aldehyde. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5035 / 5037

页数：3

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