Use of ATR inhibitor in combination with topoisomerase I inhibitor kills cancer cells by disabling DNA replication initiation and fork elongation

被引：0
|
作者：
Josse, R. [1 ]
Martin, S. E. [2 ]
Guha, R. [2 ]
Ormanoglu, P. [2 ]
Pfister, T. [3 ]
Morris, J. [4 ]
Doroshow, J. [4 ]
Pommier, Y. [1 ]
机构：
[1] NCI, Dev Therapeut Branch, Bethesda, MD 20892 USA
[2] NCATS, Div Preclin Innovat, Rockville, MD USA
[3] Leidos Biomed Res Inc, Lab Human Toxicol & Pharmacol, Frederick, MD USA
[4] DTP DCTD, Drug Synth & Chem Branch, Bethesda, MD USA
来源：
EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷
关键词：
D O I：
10.1016/S0959-8049(14)70374-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
248
引用
收藏
页码：83 / 83
页数：1
相关论文
共 50 条
  • [21] EFFECTS OF CAMPTOTHECIN, AN INHIBITOR OF DNA TOPOISOMERASE-I ON RIBOSOMAL GENE STRUCTURE AND FUNCTION IN TG CELLS
    FARABEGOLI, F
    GOVONI, M
    NOVELLO, F
    BIOLOGY OF THE CELL, 1992, 74 (03) : 281 - 286
  • [22] THE DNA TOPOISOMERASE-I INHIBITOR CAMPTOTHECIN BLOCKS POSTMITOTIC REFORMATION OF NUCLEOLI IN MAMMALIAN-CELLS
    WEISENBERGER, D
    SCHEER, U
    BENAVENTE, R
    EUROPEAN JOURNAL OF CELL BIOLOGY, 1993, 61 (01) : 189 - 192
  • [23] Narciclasine, a novel topoisomerase I inhibitor, exhibited potent anti-cancer activity against cancer cells
    Wang, Meichen
    Liang, Leilei
    Wang, Rong
    Jia, Shutao
    Xu, Chang
    Wang, Yuting
    Luo, Min
    Lin, Qiqi
    Yang, Min
    Zhou, Hongyu
    Liu, Dandan
    Qing, Chen
    NATURAL PRODUCTS AND BIOPROSPECTING, 2023, 13 (01)
  • [24] Narciclasine, a novel topoisomerase I inhibitor, exhibited potent anti-cancer activity against cancer cells
    Meichen Wang
    Leilei Liang
    Rong Wang
    Shutao Jia
    Chang Xu
    Yuting Wang
    Min Luo
    Qiqi Lin
    Min Yang
    Hongyu Zhou
    Dandan Liu
    Chen Qing
    Natural Products and Bioprospecting, 2023, 13
  • [25] Mechanism of growth inhibition of human cancer cells by conjugated eicosapentaenoic acid, an inhibitor of DNA polymerase and topoisomerase
    Yonezawa, Yuko
    Yoshida, Hiromi
    Mizushina, Yoshiyuki
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2007, 8 (12): : 1206 - 1224
  • [26] DNA strand-breaks induced by the topoisomerase I inhibitor camptothecin in unstimulated human white blood cells
    Daza, P
    Torreblanca, J
    García-Herdugo, G
    Moreno, FJ
    CELL BIOLOGY INTERNATIONAL, 2002, 26 (08) : 707 - 713
  • [27] PARG inhibition augments CHK1 inhibitor-induced replication stress and synergistically kills ovarian cancer cells
    Acharya, Ganesh
    Mani, Chinnadurai
    Reedy, Mark B.
    Palle, Komaraiah
    CANCER RESEARCH, 2023, 83 (07)
  • [28] Radiation enhancement by the combined use of topoisomerase I inhibitors, RFS-2000 or CPT-11, and topoisomerase II inhibitor etoposide in human lung cancer cells
    Kim, JS
    Amorino, GP
    Pyo, H
    Cao, QW
    Choy, H
    RADIOTHERAPY AND ONCOLOGY, 2002, 62 (01) : 61 - 67
  • [29] The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1α Activity by Changing miR Expression Patterns in Human Cancer Cells
    Bertozzi, Davide
    Marinello, Jessica
    Manzo, Stefano G.
    Fornari, Francesca
    Gramantieri, Laura
    Capranico, Giovanni
    MOLECULAR CANCER THERAPEUTICS, 2014, 13 (01) : 239 - 248
  • [30] Targeting ATR and AKT pathways promotes cell death in PARP inhibitor-resistant ovarian cancer cells by increasing DNA damage and lethal replication stress
    Huang, Tzu-Ting
    Chiang, Chih-Yuan
    Gupta, Nitasha
    Wilson, Kelli
    Cheng, Ken Chih-Chien
    Lee, Jung-Min
    CANCER RESEARCH, 2022, 82 (12)
12345