Piecewise affine systems approach to control of biological networks

被引：9

作者：

Imura, Jun-ichi ^{[1
]}

Kashima, Kenji ^{[1
]}

Kusano, Masami ^{[1
]}

Ikeda, Tsukasa ^{[2
]}

Morohoshi, Tomohiro ^{[2
]}

机构：

[1] Tokyo Inst Technol, Dept Mech & Environm Informat, Grad Sch Informat Sci & Engn, Meguro Ku, Tokyo 1528552, Japan

[2] Utsunomiya Univ, Dept Mat & Environm Chem, Grad Sch Engn, Utsunomiya, Tochigi 3218585, Japan

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2010年 / 368卷 / 1930期

基金：

日本学术振兴会;

关键词：

hybrid system; piecewise affine system; Pseudomonas aeruginosa; controllability; optimal control; PSEUDOMONAS-AERUGINOSA; CLUSTERING TECHNIQUE; HYBRID SYSTEMS; IDENTIFICATION;

D O I：

10.1098/rsta.2010.0176

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In terms of a piecewise affine system representation, which is a kind of hybrid system model, this article discusses a series of approaches to modelling, analysing and synthesizing a biological network such as a gene-regulatory network. First, the input assignment problem, the controllable state set problem (CSP) and the input trajectory generation problem are emphasized as control problems to be addressed for biological networks. Subsequently, after the modelling issue on biological networks developed in the systems and control community is briefly explained, the CSP is described in detail with reference to control of the quorum-sensing system in the pathogen Pseudomonas aeruginosa. Finally, an optimal control design method to the quorum-sensing system is proposed as a solution to the input trajectory generation problem.

引用

页码：4977 / 4993

页数：17

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