Protein tyrosine phosphatase 1B antisense oligonucleotide enhances insulin sensitivity in a model of insulin resistance

被引:0
|
作者
Zinker, B
Adler, A
Shapiro, R
Mika, A
Bush, E
Xie, N
Nguyen, P
Wilcox, D
Clampit, J
Jacobson, P
Trevillyan, J
Reilly, R
Opgenorth, T
Jirousek, M
机构
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:A331 / A331
页数:1
相关论文
共 50 条
  • [41] Antisense protein tyrosine phosphatase 1B lowers plasma glucose, increases insulin sensitivity and reverses activation of the stress kinase p38 in ob/ob mice.
    Gum, RJ
    Zinker, B
    Rondinone, C
    Clampit, J
    Waring, J
    Gaede, L
    Stark, M
    Heindel, M
    Xie, N
    Trevillyan, J
    Jirousek, M
    Ulrich, R
    DIABETOLOGIA, 2001, 44 : A78 - A78
  • [42] Sensitivity of protein tyrosine phosphatase 1B active site to the redox environment
    Salsman, SJ
    Hensley, K
    Floyd, RA
    FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 : S110 - S110
  • [43] Protein tyrosine phosphatase 1B (PTP1B) deficiency rescues insulin resistance and the diabetic phenotype in mice heterozygous for insulin receptor (IR) and insulin receptor substrate 1 (IRS1) null alleles
    Xue, BZ
    Lee, A
    Kahn, CR
    Neel, BG
    Kahn, BB
    DIABETES, 2005, 54 : A332 - A333
  • [44] Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice
    Gum, RJ
    Gaede, LL
    Koterski, SL
    Heindel, M
    Clampit, JE
    Zinker, BA
    Trevillyan, JM
    Ulrich, RG
    Jirousek, MR
    Rondinone, CM
    DIABETES, 2003, 52 (01) : 21 - 28
  • [45] In vivo inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) with an antisense oligonucleotide improves hyperglycemia and insulin sensitivity in diabetic mice
    Pandey, SK
    Michael, MD
    Sloop, KW
    Watts, L
    Rivard, AR
    Leedom, TA
    Manchem, P
    Petok, S
    McKay, RA
    Monia, BP
    Bhanot, S
    DIABETES, 2005, 54 : A22 - A23
  • [46] IDD-2846, a protein-tyrosine phosphatase 1B (PTP1B) inhibitor improves insulin sensitivity in high fat diet fed insulin resistant Wistar rats
    Fan, CD
    Dean, D
    Fang, HQ
    Sawicki, D
    Balkan, B
    DIABETES, 2003, 52 : A141 - A141
  • [47] Vitamin A improves insulin sensitivity by increasing insulin receptor phosphorylation through protein tyrosine phosphatase 1B regulation at early age in obese rats of WNIN/Ob strain
    Jeyakumar, S. M.
    Kumar, P. Vijaya
    Giridharan, N. V.
    Vajreswari, A.
    DIABETES OBESITY & METABOLISM, 2011, 13 (10): : 955 - 958
  • [48] Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes
    Gonzalez-Rodriguez, Agueda
    Clampit, Jill E.
    Escribano, Oscar
    Benito, Manuel
    Rondinone, Cristina M.
    Valverde, Angela M.
    ENDOCRINOLOGY, 2007, 148 (02) : 594 - 608
  • [49] Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity
    Cook, WS
    Unger, RH
    DEVELOPMENTAL CELL, 2002, 2 (04) : 385 - 387
  • [50] Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors from Morinda citrifolia (Noni) and Their Insulin Mimetic Activity
    Nguyen, Phi-Hung
    Yangll, Jun-Li
    Uddin, Mohammad N.
    Park, So-Lim
    Lim, Seong-Il
    Jung, Da-Woon
    Williams, Darren R.
    Oh, Won-Keun
    JOURNAL OF NATURAL PRODUCTS, 2013, 76 (11): : 2080 - 2087