Carbonyldiimidazole (CDI) Mediated Synthesis of Nα-Protected Amino Acid Azides: Application to the One-pot Preparation of Ureidopeptides

被引：2

作者：

Vasantha, B. ^{[1
]}

Vishwanatha, T. M. ^{[1
]}

Sureshbabu, Vommina V. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

来源：

PROTEIN AND PEPTIDE LETTERS | 2011年 / 18卷 / 11期

关键词：

Acyl azide; CDI; one-pot reaction; ureidopeptides; PROTEASE INHIBITORS; PEPTIDE ISOCYANATES; ACYL AZIDES; UREAS; PEPTIDOMIMETICS; DERIVATIVES; CONVERSION; CATALYSIS; CONCISE;

D O I：

10.2174/092986611797200922

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of N-alpha-protected amino acyl azides starting from corresponding acids via the carbonyldiimidazole (CDI) activation is described. The protocol is extended for a one-pot preparation of ureido peptides that circumvents the isolation of acyl azide and isocyanate intermediates. The reaction was accomplished without using any additives and base. The protocol is simple, clean, high yielding and free from racemization.

引用

页码：1093 / 1098

页数：6

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