Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

被引：0
|
作者：
Youn, Ui Joung [1 ]
Jang, Ji-Eun [1 ]
Nam, Joo-Won [1 ]
Lee, Yoo Jin [1 ]
Son, Young Min [1 ]
Shin, Hyun Ji [1 ]
Han, Ah-Reum [1 ]
Chang, Jun [1 ]
Seo, Eun-Kyoung [1 ]
机构：
[1] Ewha Womans Univ, Ctr Cell Signaling & Drug Discovery Res, Coll Pharm, Seoul 120750, South Korea
来源：
JOURNAL OF MEDICINAL PLANTS RESEARCH | 2011年 / 5卷 / 07期
关键词：
Liliaceae; Anemarrhena asphodeloides; timosaponin A-III; respiratory syncytial virus (RSV); NYASOL;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 mu M.
引用
收藏
页码：1062 / 1065
页数：4
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