The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow

被引：6

作者：

Lichtenegger, Georg J. ^{[1
]}

Tursic, Vitan ^{[1
]}

Kitzler, Hannes ^{[2
]}

Obermaier, Klemens ^{[2
]}

Khinast, Johannes G. ^{[1
,3
]}

Gruber-Woelfler, Heidrun ^{[1
,3
]}

机构：

[1] Graz Univ Technol, Inst Proc & Particle Engn, NAWI Graz, Inffeldgasse 13-3, A-8010 Graz, Austria

[2] One A Engn Austria GmbH, Seestr 11, A-4844 Regau, Austria

[3] Res Ctr Pharmaceut Engn GmbH, Inffeldgasse 13, A-8010 Graz, Austria

来源：

CHEMIE INGENIEUR TECHNIK | 2016年 / 88卷 / 10期

关键词：

Acetylsalicylic acid; Continuous Suzuki-Miyaura reaction; Esterification; Fixed-bed reactor; Heterogeneous catalysis; Modular continuous reactors; ACTIVE PHARMACEUTICAL INGREDIENTS; CROSS-COUPLING REACTIONS; PALLADIUM CATALYSTS; CHEMISTRY; ESTERIFICATION; PRODUCTS; SYSTEMS; BATCH;

D O I：

10.1002/cite.201600013

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The so-called plug & play reactor is a novel reaction device with exchangeable reaction segments as well as modules for heating/cooling and mixing. Its performance is demonstrated for two model processes: the production of acetylsalicylic acid with a fixed bed of commercial ion-exchange particles and a Suzuki-Miyaura cross-coupling with a solid Pd-catalyst developed by us. The reaction progress was monitored by inline UV-vis spectroscopy and compared with offline HPLC. The novel set-up leads to quantitative yields and selectivity as well as to an improved practicability of the processes.

引用

页码：1518 / 1523

页数：6

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