Can FSH influence longevity?

被引：8
|
作者：
Bartke, Andrzej [1 ]
机构：
[1] SIU Sch Med, Dept Internal Med, 801 N Rutledge,POB 19628, Springfield, IL 62704 USA
来源：
AGING CELL | 2017年 / 16卷 / 05期
关键词：
Aging; life span; longevity; longevity regulation; mice; molecular biology of aging; AMES DWARF MICE; BROWN ADIPOSE-TISSUE; TRANSGENIC MICE; GROWTH;
D O I：
10.1111/acel.12663
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It was recently reported that the extragonadal actions of follicle-stimulating hormone (FSH) include regulation of brown and white adipose tissue function and thermogenesis. Based on these findings and on our evidence for reduced FSH levels and enhanced thermogenesis in long-lived growth hormone (GH)-deficient mice and GH-resistant mice, we suggest that FSH may have a role in the control of aging and longevity. We speculate that alterations in FSH secretion may represent one of the mechanisms of trade-offs between reproduction and aging.
引用
收藏
页码：916 / 917
页数：2
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