Two New Clerodane Diterpenes from Tinospora sagittata

被引：11
|
作者：
Li, Guanhua [1 ]
Ding, Wenbing [1 ,2 ]
Wan, Fanghao [1 ,3 ]
Li, Youzhi [1 ,2 ]
机构：
[1] Hunan Agr Univ, Coll Plant Protect, Changsha 410128, Hunan, Peoples R China
[2] Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha 410128, Hunan, Peoples R China
[3] Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
来源：
MOLECULES | 2016年 / 21卷 / 09期
关键词：
Tinospora sagittata; clerodane diterpenes; alpha-glucosidase inhibitory activity; PLANTS; ROOTS;
D O I：
10.3390/molecules21091250
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and -glucosidase inhibitory activities of isolated compounds were evaluated in vitro.
引用
下载
收藏
页数：8
相关论文
共 50 条
  • [11] Two New Clerodane Diterpenes from Dodonaea viscosa
    Huang, Zheng
    Jiang, Meng-Yuan
    Zhou, Zhong-Yu
    Xu, Di
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2010, 65 (01): : 83 - 86
  • [12] Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia
    Phan Van Kiem
    Chau Van Minh
    Nguyen Tien Dat
    La Van Kinh
    Dan Thuy Hang
    Nguyen Hoai Nam
    Nguyen Xuan Cuong
    Hoang Thanh Huong
    Trinh Van Lau
    FITOTERAPIA, 2010, 81 (06) : 485 - 489
  • [13] Tinospinosides D, E, and Tinospin E, Further Clerodane Diterpenoids from Tinospora sagittata
    Huang, Chao
    Li, Wei
    Ma, Fenghua
    Li, Qin
    Asada, Yoshihisa
    Koike, Kazuo
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, 60 (10) : 1324 - 1328
  • [14] Clerodane-type diterpenoids from tuberous roots of Tinospora sagittata (Oliv.) Gagnep
    Zhang, Geng
    Ma, Haoran
    Hu, Song
    Xu, Hongfeng
    Yang, Bo
    Yang, Quanwei
    Xue, Yongbo
    Cheng, Lu
    Jiang, Jie
    Zhang, Jinwen
    Wang, Fuqian
    Zhang, Yonghui
    FITOTERAPIA, 2016, 110 : 59 - 65
  • [15] Two New neo-clerodane Diterpenes from Scutellaria galericulata
    Nicolova, Katia
    Kusz, Norbert
    Hohmann, Judit
    Naydenov, Mladen
    Bozov, Petko
    CHEMISTRY OF NATURAL COMPOUNDS, 2018, 54 (01) : 77 - 80
  • [16] Two New neo-clerodane Diterpenes from Scutellaria galericulata
    Katia Nicolova
    Norbert Kusz
    Judit Hohmann
    Mladen Naydenov
    Petko Bozov
    Chemistry of Natural Compounds, 2018, 54 : 77 - 80
  • [17] Two new clerodane diterpenes with antibacterial activity from Ajuga lupulina
    Chen, H
    Liu, DQ
    Zhang, LX
    Xia, ZH
    Yang, L
    Liu, ZL
    Tan, RX
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1999, 38 (06): : 743 - 745
  • [18] Two new neo-clerodane diterpenoids from Tinospora cordifolia stems
    Hoang, Nhat Nam
    Hoshino, Shotaro
    Kodama, Takeshi
    Hoang, Thao Xuan
    Onaka, Hiroyasu
    Morita, Hiroyuki
    PHYTOCHEMISTRY LETTERS, 2024, 63 : 54 - 59
  • [19] New Clerodane diterpenes from Zuelania guidonia
    Calderon, C.
    Castro, V
    Murillo, R.
    PLANTA MEDICA, 2012, 78 (11) : 1174 - 1175
  • [20] Clerodane diterpenoids with in-vitro anti-neuroinflammatory activity from the tuberous root of Tinospora sagittata (Menispermaceae)
    Song, Jia-Qi
    Deng, Li
    Zhu, Yang-Li
    Zhou, Hong
    Kong, Xiang-Qian
    Zhang, Li-Jun
    Liao, Hai-Bing
    PHYTOCHEMISTRY, 2024, 218
12345