A One-pot Facile Construction of 1H-1,2,3-Triazolyl 1,2-Dihydropyridyl Derivatives and Evaluation of Bioactivity Profile

被引：4

作者：

Rajkumar, Kommera ^{[1
,4
]}

Murthy, Thampunuri Ramalinga ^{[2
]}

Zehra, Amtul ^{[3
]}

Khursade, Parag Sakharam ^{[1
]}

Kaliyendi, Shasi Vardhan ^{[2
]}

Tiwari, Ashok Kumar ^{[3
]}

Prakasham, Reddy Shetty ^{[1
]}

Raju, Bhimapaka China ^{[1
,4
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Organ Synth & Proc Chem Div, Hyderabad 500007, India

[2] CSIR, Indian Inst Chem Technol, Appl Biol Div, Hyderabad 500007, India

[3] CSIR, Indian Inst Chem Technol, Ctr Nat Prod & Tradit Knowledge, Hyderabad 500007, India

[4] AcSIR Postal Staff Coll Area, Sect 19, Ghaziabad 201002, Uttar Pradesh, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 48期

关键词：

Anti-inflammatory activity; Antiproliferative activity; Chromones; 1,2-Dihydropyridine-3-carboxylates; alpha-Glucosidase inhibitory activity; 3-Oxobutanoates; CELL-LINES; BENZOPHENONES; ANNULATION; INHIBITORS; CHROMONE;

D O I：

10.1002/slct.201802809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot, facile method has been established for the preparation of 1H-1,2,3-triazolyl 1,2-dihydropyridyl derivatives 6 a-y. The ring opening of the chromone and cyclo addition are the notable reactions to achieve the target compounds 6 a-y. All the compounds were screened for their antiproliferative, free radical scavenging (DPPH, ABTS(.+)), alpha-glucosidase inhibitory and anti-inflammatory activities. The bioactivity profile revealed that the compounds 6 x-y were shown potent antiproliferative activity against HeLa cell line, while compounds 6 e-h and 6 w identified as potent ABTS(+.) and 6 n identified as potent DPPH free radical scavenger. Compounds 6 h-i, 6 p-r, 6 u and 6 w denoted promising anti-inflammatory activity.

引用

页码：13729 / 13735

页数：7

共 50 条

[21] EFFICIENT ONE-POT SYNTHESIS OF POLYSUBSTITUTED 6-[(1H-1,2,3-TRIAZOL-1-YL)METHYL]URACILS THROUGH THE "CLICK" PROTOCOL
Jansa, Petr
Spacek, Petr
Votruba, Ivan
Brehova, Petra
Dracinsky, Martin
Klepetarova, Blanka
Janeba, Zlatko
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 2011, 76 (09) : 1121 - 1131
[22] Efficient synthesis of α(1,2)-linked oligomannoside derivatives through one-pot glycosylation
Sano, Kanae
Ishii, Nozomi
Kosugi, Misa
Kuroiwa, Ayumi
Matsuo, Ichiro
CARBOHYDRATE RESEARCH, 2020, 494
[23] A Facile One-Pot Metal-Free Synthesis of 1,4-Disubstituted 1,2,3-Triazoles
Jia, Qianfa
Yang, Gongming
Chen, Lei
Du, Zhiyun
Wei, Jia
Zhong, Yanqiong
Wang, Jian
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015, 2015 (16) : 3435 - 3440
[24] Designing Click One-Pot Synthesis and Antidiabetic Studies of 1,2,3-Triazole Derivatives
Shafique, Kainat
Farrukh, Aftab
Mahmood Ali, Tariq
Qasim, Sumera
Jafri, Laila
Abd-Rabboh, Hisham S. M.
AL-Anazy, Murefah Mana
Kalsoom, Saima
MOLECULES, 2023, 28 (07):
[25] Synthesis of β-(N-1,2,3-triazolyl)-substituted α,β-unsaturated α-amino acid derivatives.: A new example of 1H- to 2H-1,2,3-triazole isomerisation
Polak, M
Vercek, B
SYNTHETIC COMMUNICATIONS, 2000, 30 (16) : 2863 - 2871
[26] ONE-POT SYNTHESIS OF 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)-1-PHENYL-1H-[1,2,3] TRIAZOLE DERIVATIVES AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY
Subhashini, N. J. P.
Reddy, Ch. Bhaskar
Kumar, P. Ashok
Lingaiah, B.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 25 (02) : 177 - 180
[27] REACTIVITY OF 2-(1-METHYL-1H-BENZO[d]IMIDAZOL-2-YL)-2-NITROSOACETONITRILE: A FACILE ONE-POT SYNTHESIS OF BENZIMIDAZO[1,2-a]PIPERAZINE DERIVATIVES
Sayed, Samia M.
Khalil, Mohamed A.
Raslan, Mohamed A.
HETEROCYCLES, 2015, 91 (04) : 824 - 834
[28] Facile synthesis of 1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives by a one-pot, three-component reactions
Teimouri, Mohammad Bagher
Mansouri, Farideh
Bazhrang, Reihaneh
TETRAHEDRON, 2010, 66 (01) : 259 - 264
[29] A Facile One-Pot Synthesis and Anticancer Evaluation of Novel Substituted 1,2-Dihydropyridine and 1,2,3,4-Tetrahydropyrimidine Analogues
Bari, Ahmed
Parvez, Mohammad Khalid
Khan, Azmat Ali
Alanazi, Amer M.
Syed, Saeed Ali
Al-Dosari, Mohammed S.
Alobaid, Abdulrahman M.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (02) : 377 - 382
[30] Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach
Demjen, Andras
Gyuris, Mario
Woelfling, Janos
Puskas, Laszlo G.
Kanizsai, Ivan
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014, 10 : 2338 - 2344

← 1 2 3 4 5 →