A One-pot Facile Construction of 1H-1,2,3-Triazolyl 1,2-Dihydropyridyl Derivatives and Evaluation of Bioactivity Profile

被引：4

作者：

Rajkumar, Kommera ^{[1
,4
]}

Murthy, Thampunuri Ramalinga ^{[2
]}

Zehra, Amtul ^{[3
]}

Khursade, Parag Sakharam ^{[1
]}

Kaliyendi, Shasi Vardhan ^{[2
]}

Tiwari, Ashok Kumar ^{[3
]}

Prakasham, Reddy Shetty ^{[1
]}

Raju, Bhimapaka China ^{[1
,4
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Organ Synth & Proc Chem Div, Hyderabad 500007, India

[2] CSIR, Indian Inst Chem Technol, Appl Biol Div, Hyderabad 500007, India

[3] CSIR, Indian Inst Chem Technol, Ctr Nat Prod & Tradit Knowledge, Hyderabad 500007, India

[4] AcSIR Postal Staff Coll Area, Sect 19, Ghaziabad 201002, Uttar Pradesh, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 48期

关键词：

Anti-inflammatory activity; Antiproliferative activity; Chromones; 1,2-Dihydropyridine-3-carboxylates; alpha-Glucosidase inhibitory activity; 3-Oxobutanoates; CELL-LINES; BENZOPHENONES; ANNULATION; INHIBITORS; CHROMONE;

D O I：

10.1002/slct.201802809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot, facile method has been established for the preparation of 1H-1,2,3-triazolyl 1,2-dihydropyridyl derivatives 6 a-y. The ring opening of the chromone and cyclo addition are the notable reactions to achieve the target compounds 6 a-y. All the compounds were screened for their antiproliferative, free radical scavenging (DPPH, ABTS(.+)), alpha-glucosidase inhibitory and anti-inflammatory activities. The bioactivity profile revealed that the compounds 6 x-y were shown potent antiproliferative activity against HeLa cell line, while compounds 6 e-h and 6 w identified as potent ABTS(+.) and 6 n identified as potent DPPH free radical scavenger. Compounds 6 h-i, 6 p-r, 6 u and 6 w denoted promising anti-inflammatory activity.

引用

页码：13729 / 13735

页数：7

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