Dipeptide Inhibitors as Potent Botulinum Neurotoxin Type A Light Chain Inhibitors

被引:0
|
作者
Amezcua, Martin [1 ]
Cruz, Ricardo S. [1 ]
Ku, Alex [1 ]
Moran, Wilfred [1 ]
Ortega, Marcos E. [2 ]
Salzameda, Nicholas T. [1 ]
机构
[1] Calif State Univ Fullerton, Dept Chem & Biochem, Fullerton, CA 92634 USA
[2] Texas Tech Univ, Woody L Hunt Sch Dent Med, El Paso, TX USA
关键词
Botulinum neurotoxin light chain; Drug discovery; Enzyme assay; Peptides; Small molecule inhibitors; X-ray crystallography;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:S4 / S4
页数:1
相关论文
共 50 条
  • [31] Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors
    Li, Bing
    Pai, Ramdas
    Cardinale, Steven C.
    Butler, Michelle M.
    Peet, Norton P.
    Moir, Donald T.
    Bavari, Sina
    Bowlin, Terry L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (05) : 2264 - 2276
  • [32] Synthesis of small-molecule inhibitors of botulinum neurotoxin
    Recabo, Katlin
    Slick, Elizabeth
    Ensel, Susan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [33] Synthesis and biological evaluation of inhibitors of botulinum neurotoxin metalloprotease
    Widom, Julia R.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [34] Design and synthesis of inhibitors of botulinum neurotoxin A and B metalloproteases
    Oost, TK
    Sukonpan, C
    Rich, DH
    PEPTIDES FOR THE NEW MILLENNIUM, 2000, : 24 - 25
  • [35] SYNTHESIS AND BIOLOGICAL EVALUATION OF INHIBITORS OF BOTULINUM NEUROTOXIN METALLOPROTEASE
    Wang, Chenbo
    Widom, Julia
    Petronijevic, Filip
    Burnett, James C.
    Nuss, Jonathan E.
    Bavari, Sina
    Gussio, Rick
    Wipf, Peter
    HETEROCYCLES, 2009, 79 : 487 - 520
  • [36] Preparation of a chimera molecule composed of botulinum neurotoxin heavy chain and IgG against the botulinum neurotoxin light chain
    Tabata, Y
    Yotsuya, K
    Torii, Y
    Aoyagi, K
    Morimatsu, M
    Syuto, B
    JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2000, 53 (01) : 32 - 45
  • [37] BOTULINUM NEUROTOXIN TYPE-A RADIOLABELED AT EITHER THE LIGHT OR THE HEAVY-CHAIN
    DEKLEVA, ML
    DASGUPTA, BR
    SATHYAMOORTHY, V
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1989, 274 (01) : 235 - 240
  • [38] Endopeptidase Activities of Botulinum Neurotoxin Type B Complex, Holotoxin, and Light Chain
    Wang, Hai-Hong
    Riding, Stephen
    Lindo, Paul
    Singh, Bal Ram
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2010, 76 (19) : 6658 - 6663
  • [39] Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds
    Minnow, Yacoba V. T.
    Goldberg, Ronald
    Tummalapalli, Sreedhar R.
    Rotella, David P.
    Goodey, Nina M.
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2017, 618 : 15 - 22
  • [40] Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease
    Oost, T
    Sukonpan, C
    Brewer, M
    Goodnough, M
    Tepp, W
    Johnson, EA
    Rich, DH
    BIOPOLYMERS, 2003, 71 (06) : 602 - 619