EPR Studies of DOPA-Melanin Complexes with Fe(III)

被引：26
|
作者：
Zdybel, Magdalena [1 ]
Chodurek, Ewa [2 ]
Pilawa, Barbara [1 ]
机构：
[1] Med Univ Silesia, Dept Biophys, Sch Pharm, PL-41200 Sosnowiec, Poland
[2] Med Univ Silesia, Dept Biopharm, Sch Pharm, PL-41200 Sosnowiec, Poland
来源：
APPLIED MAGNETIC RESONANCE | 2011年 / 40卷 / 01期
关键词：
ELECTRON-SPIN-RESONANCE; FREE-RADICALS; BINDING-SITES; PARAMAGNETIC CENTERS; SYNTHETIC MELANIN; METAL-BINDING; NEUROMELANIN; EUMELANINS; OXIDATION; CU2+;
D O I：
10.1007/s00723-010-0187-z
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
Paramagnetic centers in 3,4-dihydroxyphenylalanine-melanin and its complexes with Fe(III) were examined by electron paramagnetic resonance (EPR) spectroscopy. Paramagnetic centers of melanin play an important role in detoxification of environment and they reveal high activity in binding of metal ions. Two different signals were observed in EPR spectra: lines of o-semiquinone free radicals and lines of paramagnetic Fe(III). Amplitudes of EPR lines of both free radicals and iron ions decrease with increasing Fe(III) content in melanin-metal ion complexes. Free radical concentrations in the melanin samples, g-factors, amplitudes and line widths of EPR spectra were determined. It was stated that fast spin-lattice relaxation processes exist in both free radical system and paramagnetic iron ions in melanin complexes.
引用
收藏
页码：113 / 123
页数：11
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