Determination of the diffusion coefficient of rivanol in dentin of a human tooth in vitro

In the work, the effective diffusion coefficient of an aqueous solution of the pharmaceutical preparation rivanol in slices of human tooth dentin was experimentally determined using the method of reflection spectroscopy. Within the framework of the free diffusion model, in calculations using the second Fick law and the Bouguer-Lambert-Beer law for the optical model, the effective diffusion coefficient of the photosensitizer was calculated, which turned out to be equal on average (2.27 +/- 0.32).10(-6) cm(2)/s (n = 10).