On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells

被引：21
|
作者：
Ntolkeras, Georgios [1 ]
Barba, Chrysanthi [1 ]
Mavropoulos, Athanasios [1 ]
Vasileiadis, Georgios K. [1 ]
Dardiotis, Efthymios [2 ]
Sakkas, Lazaros I. [1 ]
Hadjigeorgiou, Georgios [2 ,3 ]
Bogdanos, Dimitrios P. [1 ]
机构：
[1] Univ Thessaly, Univ Gen Hosp Larissa, Sch Hlth Sci, Dept Rheumatol & Clin Immunol,Fac Med, Biopolis 40500, Larissa, Greece
[2] Univ Thessaly, Univ Gen Hosp Larissa, Sch Hlth Sci, Dept Neurol & Lab Neurogenet,Fac Med, Viopolis 40500, Larissa, Greece
[3] Univ Cyprus, Sch Med, Dept Neurol, Nicosia, Cyprus
来源：
IMMUNOLOGIC RESEARCH | 2019年 / 67卷 / 4-5期
关键词：
Autoimmunity; Demyelination; Inflammation; Regulation; Statin; REGULATORY T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; COA REDUCTASE INHIBITORS; MODIFIED DENDRITIC CELLS; HIGH-DOSE SIMVASTATIN; IMMUNOMODULATORY SYNERGY; MONOCLONAL-ANTIBODIES; ANTIGEN PRESENTATION; GLATIRAMER ACETATE; ENDOTHELIAL-CELLS;
D O I：
10.1007/s12026-019-09089-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess their clinical significance in autoimmune disease, such as multiple sclerosis (MS), a chronic progressive demyelinating disease of autoimmune nature. The dysregulated immunity noted in MS features a profound shift from Tregs dominance to Th17 cell superiority. In this review, we discuss the immunobiological basis of statins, their role in autoimmunity related to MS, and the data from experimental models and human studies on their effect on Th17 cells.
引用
收藏
页码：310 / 324
页数：15
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