The Development of the Corpus Callosum in the Healthy Human Brain

被引:191
|
作者
Luders, Eileen [1 ]
Thompson, Paul M. [1 ]
Toga, Arthur W. [1 ]
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuro Imaging, Los Angeles, CA 90095 USA
来源
JOURNAL OF NEUROSCIENCE | 2010年 / 30卷 / 33期
基金
美国国家卫生研究院;
关键词
SEX-DIFFERENCES; ADOLESCENCE; CHILDHOOD; MRI; MATURATION; CHILDREN; GRAY; DEGENERATION; VARIABILITY; DIMORPHISM;
D O I
10.1523/JNEUROSCI.5122-09.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The corpus callosum changes structurally throughout life, but most dramatically during childhood and adolescence. Even so, existing studies of callosal development tend to use parcellation schemes that may not capture the complex spatial profile of anatomical changes. Thus, more detailed mapping of callosal growth processes is desirable to create a normative reference. This will help to relate and interpret other structural, functional, and behavioral measurements, both from healthy subjects and pediatric patients. We applied computational surface-based mesh-modeling methods to analyze callosal morphology at extremely high spatial resolution. We mapped callosal development and explored sex differences in a large and well matched sample of healthy children and adolescents (n = 190) aged 5-18 years. Except for the rostrum in females, callosal thickness increased across the whole surface, with sex-and region-specific rates of growth, and at times shrinkage. The temporally distinct changes in callosal thickness are likely to be a consequence of varying degrees of axonal myelination, redirection, and pruning. Alternating phases of callosal growth and shrinkage may reflect a permanent adjustment and fine-tuning of fibers connecting homologous cortical areas during childhood and adolescence. Our findings emphasize the importance of taking into account sex differences in future studies, as existing developmental effects might remain disguised (or biased toward the effect of the dominant sex in unbalanced statistical designs) when pooling male and female samples.
引用
收藏
页码:10985 / 10990
页数:6
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