Efficient organocatalytic asymmetric synthesis of 2-amino-4H-chromene-3-carbonitrile derivatives

被引：83

作者：

Gao, Yu ^{[1
]}

Yang, Wen ^{[1
]}

Du, Da-Ming ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE MICHAEL ADDITION; HYDROGEN-BONDING DONORS; ONE-POT SYNTHESIS; HIGHLY EFFICIENT; AQUEOUS-MEDIA; BIFUNCTIONAL ORGANOCATALYSTS; CONJUGATE ADDITION; CHIRAL SQUARAMIDES; NITROALKENES; THIOUREA;

D O I：

10.1016/j.tetasy.2012.02.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The organocatalytic enantioselective tandem Michael addition-cyclization of malononitrile to nitroalkenes for the direct synthesis of chiral 2-amino-4H-chromene-3-carbonitrile derivatives was investigated. Good yields and enantioselectivities (up to 91% ee) were achieved. This organocatalytic asymmetric tandem Michael addition-cyclization provides an efficient route toward the synthesis of optically active functionalized chromenes. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：339 / 344

页数：6

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