Novel predictive biomarkers of response to immune checkpoint blockade with nivolumab ± ipilimumab in the TITAN-RCC phase 2 trial.

被引:0
|
作者
Grimm, Marc-Oliver
Kesselmeier, Miriam
Leucht, Katharina
Schumacher, Ulrike
Tunger, Antje
Rober, Nadja
Conrad, Karsten
Sommer, Ulrich
Baretton, Gustavo Bruno
Scherag, Andre
Albiges, Laurence
Esteban, Emilio
Barthelemy, Philippe
Schmidinger, Manuela
Busch, Jonas
Perez-Valderrama, Begona
de Velasco, Guillermo
Duran, Ignacio
Schmitz, Marc
Wehner, Rebekka
机构
[1] Jena Univ Hosp, Dept Urol, Jena, Germany
[2] Jena Univ Hosp, Inst Med Stat Comp & Data Sci, Jena, Germany
[3] Jena Univ Hosp, Ctr Clin Studies, Jena, Germany
[4] Tech Univ Dresden, Fac Med Carl Gustav Carus, Inst Immunol, Dresden, Germany
[5] Univ Hosp Carl Gustav Carus, Inst Pathol, Dresden, Germany
[6] Univ Paris Sud, Gustave Roussy Canc Campus, Dept Canc Med, Villejuif, France
[7] Hosp Univ Cent Asturias, Dept Med Oncol, Oviedo, Spain
[8] Inst Cancerol Strasbourg Europe, Dept Med Oncol, Strasbourg, France
[9] Med Univ Wien, Vienna Gen Hosp AKH, Dept Internal Med 1, Vienna, Austria
[10] Univ Hosp Charite Berlin, Dept Urol, Berlin, Germany
[11] Hosp Univ Virgen Rocio, Dept Med Oncol, Seville, Spain
[12] Hosp 12 Octubre, Dept Oncol, Madrid, Spain
[13] Hosp Univ Marques Valdecilla, Dept Med Oncol, Santander, Spain
[14] Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Immunol, Dresden, Germany
关键词
D O I
10.1200/JCO.2022.40.6_suppl.367
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
367
引用
收藏
页数:3
相关论文
共 50 条
  • [41] Association of LAG-3 expression in circulating T cells and response to combination temozolomide (TMZ) and nivolumab (NIVO) in advanced neuroendocrine neoplasms (NENs): Results from an investigator-initiated phase 2 trial.
    Sukrithan, Vineeth
    Benner, Brooke
    Wei, Lai
    Goyal, Ashima
    Zhou, Ye
    Suffren, Sheryl-Ann
    Pilcher, Carly
    Christenson, Gwen
    Curtis, Nancy
    Schwarz, Emily
    Savardekar, Himanshu
    Norman, Ruthann
    Kleiber, Barbara
    Wesolowski, Robert
    Otterson, Gregory Alan
    Verschraegen, Claire F.
    Carson, William Edgar
    Shah, Manisha H.
    Konda, Bhavana
    Owen, Dwight Hall
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [42] Impact of Immune response-associated gene polymorphisms on tumor response in rectal cancer patients treated with capecitabine plus /- oxaliplatine and radiation in the ACCORD-12/PRODIGE-2 phase III trial.
    Boige, Valerie
    Mollevi, Caroline
    Chaput, Nathalie
    Gourgou, Sophie
    Azria, David
    Seitz, Jean-Francois
    Bigot, Ludovic
    Juzyna, Beata
    Miran, Isabelle
    Gerard, Jean-Pierre
    Laurent-Puig, Pierre
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [43] Efficacy and safety of QL1706, a novel dual immune checkpoint blockade containing a mixture of anti-PD1 IgG4 and anti-CTLA4 IgG1 antibodies, for advanced cervical cancer: Cohort data from a phase 1b trial.
    Liu, Jihong
    Liu, Naifu
    Wang, Danbo
    Li, Dapeng
    Fang, Cheng
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [44] Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
    Rizvi, Naiyer A.
    Mazieres, Julien
    Planchard, David
    Stinchcombe, Thomas E.
    Dy, Grace K.
    Antonia, Scott J.
    Horn, Leora
    Lena, Herve
    Minenza, Elisa
    Mennecier, Bertrand
    Otterson, Gregory A.
    Campos, Luis T.
    Gandara, David R.
    Levy, Benjamin P.
    Nair, Suresh G.
    Zalcman, Gerard
    Wolf, Juergen
    Souquet, Pierre-Jean
    Baldini, Editta
    Cappuzzo, Federico
    Chouaid, Christos
    Dowlati, Afshin
    Sanborn, Rachel
    Lopez-Chavez, Ariel
    Grohe, Christian
    Huber, Rudolf M.
    Harbison, Christopher T.
    Baudelet, Christine
    Lestini, Brian J.
    Ramalingam, Suresh S.
    LANCET ONCOLOGY, 2015, 16 (03): : 257 - 265
  • [45] Broad Antibody and Cellular Immune Response From a Phase 2 Clinical Trial With a Novel Multivalent Poxvirus-Based Respiratory Syncytial Virus Vaccine
    Jordan, Elke
    Lawrence, Steven J.
    Meyer, Thomas P. H.
    Schmidt, Darja
    Schultz, Stephanie
    Mueller, Jutta
    Stroukova, Daria
    Koenen, Brigitte
    Gruenert, Robert
    Silbernagl, Guenter
    Vidojkovic, Sanja
    Chen, Liddy M.
    Weidenthaler, Heinz
    Samy, Nathaly
    Chaplin, Paul
    JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (06): : 1062 - 1072
  • [46] PHASE 2 TRIAL OF NEOADJUVANT AND ADJUVANT PD-1 CHECKPOINT BLOCKADE IN LOCAL-REGIONALLY ADVANCED, RESECTABLE HNSCC INDICATES PATHOLOGICAL RESPONSE IS ASSOCIATED WITH HIGH DISEASE-FREE SURVIVAL
    Wise-Draper, Trisha
    Gulati, Shuchi
    Takiar, Vinita
    Palackdharry, Sarah
    Worden, Francis
    Old, Matthew
    Kaczmar, John
    Dunlap, Neal
    Hinrichs, Benjamin
    Bell, Diana
    Patil, Yash
    Riaz, Muhammad Kashif
    Weatherford, Layne
    Hamilton, Aubrey
    Lanverman, Sheena
    Mierzwa, Michelle
    Casper, Keith
    Mark, Jonathan
    Tang, Alice
    Zender, Chad
    Gillenwater, Ann
    Medvedovich, Mario
    Lee, J. Jack
    Jandarov, Roman
    Gillison, Maura
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A484 - A485
  • [47] An assessment of disease features and immune response in breast cancer patients that did not recur after receiving HER2 peptide, AE37 vaccine in a randomized phase II trial.
    Hale, Diane F.
    Perez, Sonia A.
    Vreeland, Timothy J.
    Trappey, Alfred F.
    Dabney, Raetasha Sheavette
    Berry, John S.
    Ardavanis, Alexandros
    Sears, Alan K.
    Papamichail, Michael
    Clifton, Guy T.
    Pappou, Efi
    Patil, Ritesh
    Anastasopoulou, Eleftheria
    Ponniah, Sathibalan
    Shumway, Nathan M.
    Peoples, George Earl
    Mittendorf, Elizabeth Ann
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [48] Quality of life (QoL) of OSE2101 in patients with HLA-A2+non-small cell lung cancer (NSCLC) after failure to immune checkpoint inhibitors (IO): Final data of phase 3 Atalante-1 randomized trial.
    Besse, Benjamin
    Campelo, Rosario Garcia
    Cobo-Dols, Manuel
    Quoix, Elisabeth Anne
    Madroszyk, Anne
    Felip, Enriqueta
    Cappuzzo, Federico
    Denis, Fabrice
    Hilgers, Werner
    Romano, Giampiero
    Debieuvre, Didier
    Galetta, Domenico
    Baldini, Editta
    Ramirez, Santiago Viteri
    Phan, Minh Duc
    Schuette, Wolfgang
    Zer, Alona
    Vasseur, Berangere
    Dziadziuszko, Rafal
    Giaccone, Giuseppe
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [49] NeoRad(Low): A phase 2 trial of neoadjuvant (NA) ipilimumab plus nivolumab (ipi plus nivo) with low dose stereotactic body radiation therapy (SBRT) as an immune stimulant in patients with resectable stage IB-III non-small cell lung cancer (NSCLC)
    DiPetrillo, Thomas A.
    Garcia-Moliner, Maria
    Koffer, Paul
    Hepel, Jaroslaw T.
    Khan, Hina
    Khurshid, Humera
    Abbas, Abbas
    Birnbaum, Ariel E.
    Olszewski, Adam J.
    Ferreira, Cheyenne
    Hassinger, Faith
    McCormick, Michele Carlin
    Giesing, Hannah
    Rodrigues, Nuno
    Rosati, Vallerie
    Wood, Roxanne
    Webber, Amy
    Maleki, Sara
    Azzoli, Christopher G.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [50] Phase 2 trial of lenvatinib (LEN) plus pembrolizumab (PEMBRO) for progressive disease after PD-1/PD-L1 immune checkpoint inhibitor (ICI) in metastatic clear cell (mcc) renal cell carcinoma (RCC): Results by independent imaging review and subgroup analyses
    Lee, Chung-Han
    Shah, Amishi Yogesh
    Hsieh, James J.
    Rao, Arpit
    Pinto, Alvaro
    Bilen, Mehmet Asim
    Cohn, Allen Lee
    Di Simone, Christopher
    Shaffer, David R.
    Sarrio, Regina Girones
    Ribe, Sara Gunnestad
    Wu, Jane
    Schmidt, Emmett
    Kubiak, Peter
    Okpara, Chinyere
    Smith, Alan D.
    Young, Louise
    Motzer, Robert J.
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2020, 16 : 133 - 133