A new aryldihydronaphthalene-type lignan and other metabolites with potential anti- inflammatory activities from Corispermum mongolicum Iljin

被引:17
|
作者
Zhou, Yi [1 ]
Jin, Mei [2 ]
Jin, Chunshi [1 ]
Ye, Chao [1 ]
Wang, Jiaming [1 ]
Sun, Jinfeng [1 ]
Wei, Cheng-Xi [3 ]
Zhou, Wei [1 ]
Li, Gao [1 ]
机构
[1] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Coll Pharm, Yanji, Peoples R China
[2] Yanbian Univ Hosp, Dept Pharm, Postdoctoral Res Stn, Yanji, Peoples R China
[3] Inner Mongolia Univ Nationalities, Med Coll, Tongliao, Peoples R China
基金
中国国家自然科学基金;
关键词
Corispermum mongolicum Iljin; Chenopodiaceae; lignan; anti-inflammatory activity; PHENOLIC-COMPOUNDS;
D O I
10.1080/14786419.2018.1527835
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
One new aryldihydronaphthalene-type lignan (1) together with eight known lignans (2-4, 7-11) as well as two caffeic-acid dimers (5, 6) were isolated from an ethanol extract of the whole plant of Corispermum mongolicum Iljin (Chenopodiaceae). The chemical structures of these compounds were determined from 1D and 2D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. This study is the first demonstration of nine compounds (2 and 4-11) isolated from the Chenopodiaceae family, with one of these (3) from the genus Corispermum. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of production of nitric oxide, tumour necrosis factor-alpha, and interleukin-6 in lipopolysaccharide-induced RAW 264.7 cells.
引用
收藏
页码:225 / 232
页数:8
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