Emerging functions of placental cathepsins

被引：32
|
作者：
Mason, R. W. [1 ]
机构：
[1] Alfred I Dupont Hosp Children, Dept Biomed Res, Wilmington, DE 19803 USA
来源：
PLACENTA | 2008年 / 29卷 / 05期
关键词：
cathepsin; protease; preeclampsia; gene family;
D O I：
10.1016/j.placenta.2008.02.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A series of tandem duplications of an ancestral cathepsin L gene has given rise to a family of eight placenta-specific cathepsins in mice. These genes are differentially regulated both spatially and temporally and thus each can perform unique placental functions. Analysis of the function and expression of these genes is yielding new insights into gene regulation and proteolytic processes in placenta, and may dissect critical placental roles of the single human functional ortholog, cathepsin L. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：385 / 390
页数：6
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