PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction

被引：31
|
作者：
Campa, Carlo C. [1 ]
Franco, Irene [1 ]
Hirsch, Emilio [1 ]
机构：
[1] Univ Torino, MBC, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy
来源：
FEBS LETTERS | 2015年 / 589卷 / 14期
关键词：
Phosphoinositide; Class II alpha-isoform of phosphatidylinositol 3-kinase; PI3K-C2; alpha; Endocytosis; Exocytosis; Signal transduction; Vesicle trafficking; II PHOSPHOINOSITIDE 3-KINASE; CLATHRIN-MEDIATED ENDOCYTOSIS; TRANS-GOLGI NETWORK; PHOSPHATIDYLINOSITOL; 3-KINASE; ALPHA-ISOFORM; C2; DOMAIN; SUBSTRATE-SPECIFICITY; ENDOTHELIAL-CELLS; MEMBRANE DYNAMICS; RAB5; EFFECTORS;
D O I：
10.1016/j.febslet.2015.05.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The alpha isoform of class II PI3Ks, PI3K-C2 alpha, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2 alpha function in vesicle trafficking and its impact on cell biology and mammalian embryonic development. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1552 / 1558
页数：7
相关论文
共 50 条
  • [21] Class II PI3K-C2α regulates angiogenesis via TGFβ1-Smad2/3 signaling in endothelial cell
    Aki, Sho
    Yoshioka, Kazuaki
    Okamoto, Yasuo
    Takuwa, Yoh
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010, 60 : S76 - S76
  • [22] The class II phosphoinositide 3-kinase PI3K-C2β regulates cell migration by a PtdIns(3)P dependent mechanism
    Domin, J
    Harper, L
    Aubyn, D
    Wheeler, M
    Florey, O
    Haskard, D
    Yuan, M
    Zicha, D
    JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 205 (03) : 452 - 462
  • [23] Insulin-stimulated PI(3,4)P2 production by PI3K-C2α and activation of glucokinase gene transcription in pancreatic beta cells
    Leibiger, B.
    Moede, T.
    Barker, C. J.
    Uhles, S.
    Domin, J.
    Berggren, P. -O.
    Leibiger, I. B.
    DIABETOLOGIA, 2008, 51 : S202 - S203
  • [24] PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
    Braccini, Laura
    Ciraolo, Elisa
    Campa, Carlo C.
    Perino, Alessia
    Longo, Dario L.
    Tibolla, Gianpaolo
    Pregnolato, Marco
    Cao, Yanyan
    Tassone, Beatrice
    Damilano, Federico
    Laffargue, Muriel
    Calautti, Enzo
    Falasca, Marco
    Norata, Giuseppe D.
    Backer, Jonathan M.
    Hirsch, Emilio
    NATURE COMMUNICATIONS, 2015, 6
  • [25] PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
    Laura Braccini
    Elisa Ciraolo
    Carlo C. Campa
    Alessia Perino
    Dario L. Longo
    Gianpaolo Tibolla
    Marco Pregnolato
    Yanyan Cao
    Beatrice Tassone
    Federico Damilano
    Muriel Laffargue
    Enzo Calautti
    Marco Falasca
    Giuseppe D. Norata
    Jonathan M. Backer
    Emilio Hirsch
    Nature Communications, 6
  • [26] Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice
    Alliouachene, Samira
    Kieswich, Julius E.
    Bilanges, Benoit
    McCafferty, Kieran
    Thiemermann, Christoph
    Vanhaesebroeck, Bart
    Yaqoob, Muhammad M.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 (08) : 2688 - 2697
  • [27] Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway
    Yu, Guangyan
    Wang, Chunhua
    Song, Xiangfu
    Liu, Shimeng
    Zhang, Yixin
    Fan, Lida
    Yang, Yixue
    Huang, Yulu
    Song, Jiayi
    MOLECULAR MEDICINE REPORTS, 2019, 20 (01) : 341 - 349
  • [28] Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
    Samira Alliouachene
    Benoit Bilanges
    Claire Chaussade
    Wayne Pearce
    Lazaros C. Foukas
    Cheryl L. Scudamore
    Larissa S. Moniz
    Bart Vanhaesebroeck
    Diabetologia, 2016, 59 : 1503 - 1512
  • [29] Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
    Alliouachene, Samira
    Bilanges, Benoit
    Chaussade, Claire
    Pearce, Wayne
    Foukas, Lazaros C.
    Scudamore, Cheryl L.
    Moniz, Larissa S.
    Vanhaesebroeck, Bart
    DIABETOLOGIA, 2016, 59 (07) : 1503 - 1512
  • [30] Phosphatidylinositol 3-Kinase Class II α-Isoform PI3K-C2α Is Required for Transforming Growth Factor β-induced Smad Signaling in Endothelial Cells
    Aki, Sho
    Yoshioka, Kazuaki
    Okamoto, Yasuo
    Takuwa, Noriko
    Takuwa, Yoh
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (10) : 6086 - 6105
12345