Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202

被引：3
|
作者：
Shao, Surun [1 ,2 ]
Wang, Xueni [1 ]
She, Jianglian [1 ]
Zhang, Han [2 ]
Pang, Xiaoyan [1 ]
Lin, Xiuping [1 ,3 ]
Zhou, Xuefeng [1 ,3 ]
Liu, Yonghong [1 ,3 ]
Li, Yunqiu [2 ]
Yang, Bin [1 ,3 ]
机构：
[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,Innovat Acad Sou, Guangzhou 510301, Peoples R China
[2] Guilin Med Univ, Pharm Sch, Guilin 541004, Peoples R China
[3] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China
来源：
MOLECULES | 2022年 / 27卷 / 06期
基金：
中国国家自然科学基金;
关键词：
marine-derived fungus; Emericellopsis sp; chaetoglobosins; emeriglobosin; ENDOPHYTIC FUNGUS; NATURAL-PRODUCTS; CHAETOMIUM;
D O I：
10.3390/molecules27061823
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3-11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC50 value of 1.31 mu M, and 5 showed significant cytotoxicity against PC-3 cells, with an IC50 value of 2.32 mu M.
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页数：10
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