Clearance of Immunodeficiency-associated Vaccine-derived Poliovirus Infection With Pocapavir

被引：13

作者：

Copelyn, Julie ^{[1
,2
]}

Hincks, Jeffrey R. ^{[3
]}

Wilmshurst, Jo M. ^{[4
]}

Petersen, Wonita ^{[5
]}

Howard, Wayne ^{[6
]}

Jallow, Sabelle ^{[6
]}

Moonsamy, Shelina ^{[6
]}

Seakamela, Lerato ^{[6
]}

Suchard, Melinda ^{[6
,7
]}

Collett, Marc S. ^{[3
]}

Eley, Brian ^{[1
,2
]}

机构：

[1] Red Cross War Mem Childrens Hosp, Paediat Infect Dis Unit, Cape Town, South Africa

[2] Univ Cape Town, Dept Paediat & Child Hlth, Cape Town, South Africa

[3] ViroDef Inc, Chevy Chase, MD USA

[4] Univ Cape Town, Red Cross War Mem Childrens Hosp, Neurosci Inst, Dept Paediat Neurol, Cape Town, South Africa

[5] Univ Cape Town, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, Cape Town, South Africa

[6] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Vaccines & Immunol, Johannesburg, South Africa

[7] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Chem Pathol, Johannesburg, South Africa

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2020年 / 39卷 / 05期

关键词：

pocapavir; immunodeficiency-associated vaccine-derived poliovirus; poliovirus; primary immunodeficiency;

D O I：

10.1097/INF.0000000000002584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pocapavir exhibits antiviral activity against both polio and nonpolio enteroviruses. There is limited experience of the use of this investigational drug in young children with enteroviral infection. We describe the successful clearance of prolonged immunodeficiency-associated vaccine-derived type 3 poliovirus infection by pocapavir in an infant with underlying X-linked agammaglobulinemia.

引用

页码：435 / 437

页数：3

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