Weight gain and blood pressure

被引：10

作者：

Sundstrom, Johan ^{[1
,2
]}

Lind, Lars ^{[1
]}

Lampa, Erik ^{[3
]}

Angeras, Oskar ^{[4
,5
]}

Bachus, Erasmus ^{[6
]}

Bergstrom, Goran ^{[5
,7
]}

Carlberg, Bo ^{[8
]}

Engstrom, Gunnar ^{[6
]}

Engvall, Jan E. ^{[9
,10
,11
]}

Eriksson, Mats ^{[12
]}

Gigante, Bruna ^{[13
,14
]}

Hagstrom, Emil ^{[1
,3
]}

Hjelmgren, Ola ^{[5
,7
]}

Jansson, Jan-Hakan ^{[8
]}

Jernberg, Tomas ^{[15
]}

Mannila, Maria ^{[12
]}

Nystrom, Fredrik H. ^{[16
]}

Oldgren, Jonas ^{[1
,3
]}

Persson, Margaretha ^{[17
]}

Sandstrom, Anette ^{[8
]}

Swahn, Eva ^{[16
]}

Soderberg, Stefan ^{[8
]}

Toren, Kjell ^{[18
,19
]}

Ostgren, Carl Johan ^{[16
]}

Rosengren, Annika ^{[5
,19
]}

机构：

[1] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[2] Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia

[3] Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden

[4] Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden

[5] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden

[6] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[7] Sahlgrens Univ Hosp, Clin Physiol, Gothenburg, Sweden

[8] Umea Univ, Dept Publ Hlth & Clin Med, Sect Med, Umea, Sweden

[9] Ctr Med Image Sci & Visualizat, CMIV, Linkoping, Sweden

[10] Linkoping Univ, Dept Clin Physiol, Linkoping, Sweden

[11] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden

[12] Karolinska Univ Hosp, Stockholm, Sweden

[13] Danderyd Hosp, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden

[14] Danderyd Hosp, Karolinska Inst, Dept Cardiovasc Sci, Stockholm, Sweden

[15] Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden

[16] Linkoping Univ, Dept Med & Hlth Sci, Div Cardiovasc Med, Linkoping, Sweden

[17] Lund Univ, Skane Univ Hosp & Clin Sci Malmo, Dept Med, Lund, Sweden

[18] Univ Gothenburg, Sahlgrenska Acad, Sect Occupat & Environm Med, Dept Publ Hlth & Community Med,Inst Med, Gothenburg, Sweden

[19] Sahlgrenska Univ, Gothenburg, Sweden

来源：

JOURNAL OF HYPERTENSION | 2020年 / 38卷 / 03期

基金：

瑞典研究理事会;

关键词：

cohort; epidemiology; obesity; public health; weight gain; SCAPIS; Swedish CArdioPulmonary bioImage Study; BODY-FAT DISTRIBUTION; RISK-FACTORS; HYPERTENSION INCIDENCE; SECULAR TRENDS; MASS INDEX; OBESITY; ASSOCIATION; ADOLESCENTS; OVERWEIGHT; ADIPOSITY;

D O I：

10.1097/HJH.0000000000002298

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective: Although the causality of the obesity--hypertension association is established, the potential for prevention is not. We hypothesized that weight gain between early adulthood and mid-life is associated with higher mid-life blood pressure. Methods: We investigated the hypothesis using a large contemporaneous population-based mid-life cohort of men and women aged 50-64 years. Recalled body weight at age 20 years was self-reported, and mid-life body weight and office blood pressures were measured in accordance with a detailed protocol. Results: On average, men had gained 14.9 (95% CI 14.6-15.2) kg of weight, and women 14.6 (95% CI 14.4-14.9) kg, between age 20 years and the mid-life examination, corresponding to 0.40 (95% CI 0.39-0.41) kg/year for men and women. Both weight at age 20 years and weight at the mid-life examination were associated with mid-life blood pressures. On average, a 10 kg weight increase between age 20 years and mid-life was associated with 2.2 (95% CI 0.9-3.5) mmHg higher systolic and 1.7 (95% CI 0.9-2.5) mmHg higher diastolic mid-life blood pressure in men, and 3.2 (2.5-4.0) mmHg higher systolic and 2.4 (1.9-2.9) mmHg higher diastolic mid-life blood pressure in women. Mid-life weight was more closely associated than weight at age 20 years with mid-life blood pressure. For a given mid-life weight, blood pressure was higher in persons with higher weight gain from age 20 years. Conclusion: In sum, weight gain between early adulthood and mid-life was associated with higher mid-life blood pressure. The magnitude of the association indicates a potentially great public health impact of strategies to prevent weight gain throughout adulthood.

引用

页码：387 / 394

页数：8

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