Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia

被引：39
|
作者：
Buchanan, MS [1 ]
Edser, A [1 ]
King, G [1 ]
Whitmore, J [1 ]
Quinn, RJ [1 ]
机构：
[1] Griffith Univ, AstraZeneca R&D, Brisbane, Qld 4111, Australia
来源：
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 03期
关键词：
D O I：
10.1021/np0004597
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four cheilanthane sesterterpenoids, 25-hydroxy-13(24), 15, 17-cheilanthatrien- 19,25-olide (1), 13,16-epoxya5-hydroxy- 17-cheilanthen- 19,25-olide (2), 25-hydroxy-13(24), 17-cheilanthadien-16,19-olide (3), and 16,25-dihydroxy-13(24),17-cheilanthadien 19,25-olide (4), were isolated from the marine sponge Ircinia sp. Compounds 1, 3, and 4 are new natural products. The four compounds inhibit MSK1 (mitogen and stress activated kinase) and MAPKAPK-2 (mitogen activated protein kinase activated protein kinase), two protein kinases involved in mitogen and stress signal transduction.
引用
收藏
页码：300 / 303
页数：4
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