FGF23 beyond Phosphotropic Hormone

被引：37
|
作者：
Takashi, Yuichi [1 ,2 ]
Fukumoto, Seiji [2 ]
机构：
[1] Tokushima Univ, Diabet Therapeut & Res Ctr, Inst Adv Med Sci, 3-18-15 Kuramoto Cho, Tokushima, Tokushima 7708503, Japan
[2] Tokushima Univ, Fujii Mem Inst Med Sci, Inst Adv Med Sci, 3-18-15 Kuramoto Cho, Tokushima, Tokushima 7708503, Japan
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 11期
关键词：
FIBROBLAST-GROWTH-FACTOR; CHRONIC KIDNEY-DISEASE; DOMINANT HYPOPHOSPHATEMIC RICKETS; LEFT-VENTRICULAR HYPERTROPHY; X-LINKED HYPOPHOSPHATEMIA; VITAMIN-D METABOLISM; STAGE RENAL-DISEASE; HEMODIALYSIS-PATIENTS; MINERAL METABOLISM; PHOSPHATE COTRANSPORTER;
D O I：
10.1016/j.tem.2018.08.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. FGF23 mainly affects kidney function via the FGF receptor (FGFR)/alpha-Klotho complex. The physiological roles of FGF23 and alpha-Klotho in the regulation of mineral homeostasis have been well established. In addition, recent studies have reported that FGF23 has various effects on many other tissues, sometimes in an alpha-Klotho-independent manner, especially under pathological conditions. However, how FGF23 works in these tissues without alpha-Klotho is not entirely clear. Here we review the recent reports concerning the actions of FGF23 on various tissues and discuss the remaining questions about FGF23.
引用
收藏
页码：755 / 767
页数：13
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