FGF23 is a hormone-regulating phosphate metabolism - Unique biological characteristics of FGF23

被引：101
|
作者：
Fukumoto, Seiji
Yamashita, Takeyoshi
机构：
[1] Tokyo Univ Hosp, Dept Med, Div Nephtol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Kirin Brewery Co Ltd, Pharmaceut Res Labs, Takasaki, Gunma, Japan
来源：
BONE | 2007年 / 40卷 / 05期
关键词：
hypophosphatemia; hyperphosphatemia; FGF; vitamin D; klotho;
D O I：
10.1016/j.bone.2006.12.062
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
FGF23 was identified as the last member of FGF23 family. Recent investigations indicate that excess actions of FGF23 cause several hypophosphatemic diseases whereas deficient FGF23 activity results in hyperphosphatmic tumoral calcinosis. These results indicate that FGF23 is a hormone that regulates serum phosphate level in contrast to other FGF family members that work as local factors. Furthermore, FGF23 requires Klotho for its signaling in addition to a canonical FGF receptor. These unique characteristics of FGF23 expanded our knowledge about the diversity of FGF family members and specificity of FGF23. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1190 / 1195
页数：6
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