Hepatocellular carcinoma and cholangiocarcinoma - Different prognosis, pathogenesis and therapy

被引:14
|
作者
Tischoff, I. [1 ]
Tannapfel, A. [1 ]
机构
[1] Ruhr Univ Bochum, Inst Pathol, Bochum, Germany
来源
ZENTRALBLATT FUR CHIRURGIE | 2007年 / 132卷 / 04期
关键词
liver tumours; hepatocellular carcinoma; cholangiocarcinoma; combined hepatocellular;
D O I
10.1055/s-2007-981195
中图分类号
R61 [外科手术学];
学科分类号
摘要
Primary liver cancer is one of the most common cancer worldwide. Beside hepatocellular carcinoma (HCC), accounting for more than 80%, cholangiocarcinoma (CC) is the second most frequent primary malignant epithelial liver tumor. Combined hepatocellular-cholangiocarcinoma (HCC/CC) is a rare form of liver cancer with a frequency of 1%. Both, hepatocellular carcinoma and cholangiocarcinoma, show a wide geographical variation with low-incidence areas in North America and Europe and high incidence areas in Africa and Asia. Whereas hepatocellular carcinomas develop by malignant transformation of hepatocytes, cholangiocarcinomas arise from the small intrahepatic bile duct epithelium. The UICC-TNM classification of malignant liver tumors is applied for both tumor entities. 70-80% of hepatocellular carcinoma occur in cirrhotic liver. In high incidence areas, such as Asia and Africa, HCC is strongly associated with chronic viral hepatitis B and C and liver cirrhosis. Nutritional factors, toxins and metabolic diseases contribute also to hepato-carcinogenesis. The etiology of cholangiocarcinoma remains unclear, most occur in absence of known etiological factors. But several risk factors including hepatolithiasis, liver fluke infection, and anatomical abnormalities associated with inflammation of the biliary tract have been described.
引用
收藏
页码:300 / 305
页数:6
相关论文
共 50 条
  • [21] Hepatocellular carcinoma and cholangiocarcinoma
    Rauchfuss, F.
    Scheuerlein, H.
    Goetz, M.
    Dittmar, Y.
    Voigt, R.
    Heise, M.
    Settmacher, U.
    CHIRURG, 2010, 81 (10): : 941 - 952
  • [22] Hepatocellular carcinoma: Combination therapy improves the prognosis
    Blum, H. C. H. E.
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2008, 133 (21) : 1108 - 1108
  • [23] Comparison of Combined Hepatocellular and Cholangiocarcinoma with Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
    Won-Suk Lee
    Kwang-Woong Lee
    Jin-Seok Heo
    Sung-Ju Kim
    Seong-Ho Choi
    Yong-Il Kim
    Jae-Won Joh
    Surgery Today, 2006, 36 : 892 - 897
  • [24] Comparison of combined hepatocellular and cholangiocarcinoma with hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Lee, Won-Suk
    Lee, Kwang-Woong
    Heo, Jin-Seok
    Kim, Sung-Ju
    Choi, Seong-Ho
    Kim, Yong-Il
    Joh, Jae-Won
    SURGERY TODAY, 2006, 36 (10) : 892 - 897
  • [25] Systemic Therapy for Primary Liver Tumors Cholangiocarcinoma and Hepatocellular Carcinoma
    Sadeghi, Saeed
    Bejjani, Anthony
    Finn, Richard S.
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2019, 28 (04) : 695 - +
  • [26] Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
    Venkat, Puja S.
    Hoffe, Sarah E.
    Frakes, Jessica M.
    CANCER CONTROL, 2017, 24 (03)
  • [27] PBK/TOPK in the differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma and its involvement in prognosis of human cholangiocarcinoma
    He, Furong
    Yan, Qingguo
    Fan, Linni
    Liu, Yixiong
    Cui, Jihong
    Wang, Juanhong
    Wang, Lu
    Wang, Yingmei
    Wang, Zhe
    Guo, Ying
    Huang, Gaosheng
    HUMAN PATHOLOGY, 2010, 41 (03) : 415 - 424
  • [28] Reduced Lipid Peroxidation Predicts Unfavorable Prognosis in Hepatocellular Carcinoma, but Not Intrahepatic Cholangiocarcinoma
    Gerber, Tiemo Sven
    Witzel, Hagen Roland
    Weinmann, Arndt
    Bartsch, Fabian
    Schindeldecker, Mario
    Galle, Peter R.
    Lang, Hauke
    Roth, Wilfried
    Ridder, Dirk Andreas
    Straub, Beate Katharina
    BIOMEDICINES, 2023, 11 (09)
  • [29] Clinicopathological and immunohistochemical evaluation of cholangiocarcinoma, cholangiolocarcinoma, hepatocellular carcinoma and mixed hepatocellular carcinoma and cholangiocarcinoma
    Bassullu, N.
    Turkmen, I.
    Coban, I.
    Guler, N.
    Dayangac, M.
    Akyildiz, M.
    Yaprak, O.
    Yuzer, Y.
    Tokat, Y.
    Dogusoy, G. Bulbul
    VIRCHOWS ARCHIV, 2013, 463 (02) : 287 - 288
  • [30] Postresection Outcomes of Combined Hepatocellular Carcinoma-Cholangiocarcinoma, Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
    Yoon, Young-In
    Hwang, Shin
    Lee, Young-Joo
    Kim, Ki-Hun
    Ahn, Chul-Soo
    Moon, Deok-Bog
    Ha, Tae-Yong
    Song, Gi-Won
    Jung, Dong-Hwan
    Lee, Jong-Woo
    Hong, Seung-Mo
    Yu, Eun Sil
    Lee, Sung-Gyu
    JOURNAL OF GASTROINTESTINAL SURGERY, 2016, 20 (02) : 411 - 420