Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine

被引:6
|
作者
Bullock, Trent A. [1 ]
Berquist, Michael D. [1 ]
Baker, Lisa E. [1 ]
机构
[1] Western Michigan Univ, Dept Psychol, 1903 W Michigan Ave, Kalamazoo, MI 49008 USA
来源
BEHAVIOURAL PHARMACOLOGY | 2019年 / 30卷 / 07期
基金
美国国家卫生研究院;
关键词
bath salts; behavioral sensitization; locomotor activity; mephedrone; 3-methylenedioxymethamphetamine; 4-methylmethcathinone; rat; synthetic cathinones; PSYCHOACTIVE BATH SALTS; BEHAVIORAL SENSITIZATION; 3,4-METHYLENEDIOXYPYROVALERONE MDPV; MEPHEDRONE; 4-METHYLMETHCATHINONE; METHYLENEDIOXYPYROVALERONE MDPV; PRINCIPAL CONSTITUENT; MDMA; AMPHETAMINE; DOPAMINE; PHARMACOLOGY;
D O I
10.1097/FBP.0000000000000491
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recreational abuse of illicit synthetic cathinones is an ongoing public health concern. Recent studies indicate that the methcathinone derivative 4-methylmethcathinone (4-MMC) produces behavioral and neurochemical effects similar to the entactogen 3,4-methylenedioxymethamphetamine (MDMA). Whereas polysubstance abuse is common, most preclinical studies of drug abuse liability only evaluate the effects of single drugs. Utilizing the locomotor sensitization paradigm, the present study assessed the combined locomotor stimulant effects of 4-MMC and MDMA for induction of sensitization following repeated administration and for expression of sensitization to a challenge dose of either substance alone after a 10-day period of drug abstinence. Male Sprague-Dawley rats received once daily intraperitoneal injections of saline, 4-MMC (1.0 mg/kg or 5.0 mg/kg), MDMA (3.0 mg/kg), or a mixture containing 4-MMC (1.0 mg/kg or 5.0 mg/kg) + MDMA (3.0 mg/kg) for 7 consecutive days. Following a 10-day drug-free period, rats were given a single intraperitoneal injection of either saline, 4-MMC (1.0 or 5.0 mg/kg), or 3.0 mg/kg MDMA. Activity was recorded for 1 h immediately before and 1 h immediately after injections on days 1, 7, and 17. 4-MMC treatment failed to induce locomotor sensitization, but, when combined with MDMA, sensitization was induced to a greater extent than with MDMA alone. Furthermore, the expression of sensitization to a subsequent challenge dose of MDMA was observed only in animals previously exposed to MDMA or a 5.0 mg/kg 4-MMC + MDMA mixture. In consideration of these findings along with the fact that 4-MMC has similar neurochemical actions to MDMA, further research may be warranted to determine the abuse liability of drug mixtures including 4-MMC and MDMA.
引用
收藏
页码:566 / 573
页数:8
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