Visible-light-induced transition-metal-free defluorosilylation of α-trifluoromethylalkenes via hydrogen atom transfer of silanes

被引：16
|
作者：
Xu, Wengang [1 ]
Xia, Congjian [2 ]
Shao, Qi [2 ]
Zhang, Qiao [2 ]
Liu, Mingrui [1 ]
Zhang, Hongwei [2 ]
Wu, Mingbo [1 ,2 ]
机构：
[1] China Univ Petr China East, Coll New Energy, Qingdao 266580, Peoples R China
[2] China Univ Petr China East, Coll Chem & Chem Engn, State Key Lab Heavy Oil Proc, Qingdao 266580, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 18期
基金：
中国国家自然科学基金;
关键词：
FUNCTIONALIZED GEM-DIFLUOROALKENES; C-F; DIFLUOROALLYLATION; DEFLUOROBORYLATION; ALKYLATION; GENERATION; RADICALS; ALKENES;
D O I：
10.1039/d2qo00894g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A feasible and effective synthetic protocol for silyl gem-difluoroalkenes was reported. With the cooperation of sequential single electron transfer and hydrogen atom transfer processes catalyzed by organic photocatalysts (4-CzIPN) and (i-Pr)(3)SiSH, defluorosilylations of trifluoromethylalkenes occurred smoothly with aryl and alkyl silanes under visible light irradiation. Notably, the protocol features broad scope, transition metal-free conditions, utilization of green solvents, and validity for the late-stage functionalization of bioactive molecule derivatives.
引用
收藏
页码：4949 / 4954
页数：6
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