β1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex

被引：107

作者：

Belvindrah, Richard ^{[1
]}

Graus-Porta, Diana ^{[2
]}

Goebbels, Sandra ^{[3
]}

Nave, Klaus-Armin ^{[3
]}

Mueller, Ulrich ^{[1
]}

机构：

[1] Scripps Res Inst, Inst Childhood & Neglected Dis, Dept Cell Biol, La Jolla, CA 92073 USA

[2] Novartis Inst BioMed Res, Novartis Pharma Serv, CH-4002 Basel, Switzerland

[3] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2007年 / 27卷 / 50期

关键词：

integrin; cell migration; radial glia; cerebral cortex; nervous system; reelin;

D O I：

10.1523/JNEUROSCI.4494-07.2007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Radial glial cells in the cerebral cortex serve as progenitors for neurons and glia and guide the migration of cortical neurons. The integrin alpha 3 beta 1 is thought to mediate interactions of migrating neurons with radial glial cells and to function as a receptor for the reelin signaling molecule. Here, we challenge this view and demonstrate that beta 1 integrins in migrating neurons are not essential for the formation of cell layers in the cerebral cortex. Cortical cell layers also form normally in mice deficient in the integrin alpha 3 beta 1. However, we provide evidence that beta 1 integrins in radial glia control the morphological differentiation of both glia and neurons. We conclude that beta 1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta 1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling.

引用

页码：13854 / 13865

页数：12

共 50 条

[31] GLIA-NERVE CELL INDEX FOR THE CEREBRAL CORTEX OF THE WHALE
HAWKINS, A
ANATOMICAL RECORD, 1957, 127 (02): : 422 - 422
[32] Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex
Schmid, RS
McGrath, B
Berechid, BE
Boyles, B
Marchionni, M
Sestan, N
Anton, ES
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 4251 - 4256
[33] SPARC-like 1 regulates the terminal phase of radial glia-guided migration in the cerebral cortex
Gongidi, V
Ring, C
Moody, M
Brekken, R
Sage, EH
Rakic, P
Anton, ES
NEURON, 2004, 41 (01) : 57 - 69
[34] Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development
Nowakowski, Tomasz J.
Pollen, Alex A.
Sandoval-Espinosa, Carmen
Kriegstein, Arnold R.
NEURON, 2016, 91 (06) : 1219 - 1227
[35] ASTROCYTE-SPECIFIC PROTEIN AND RADIAL GLIA IN CEREBRAL-CORTEX OF NEWBORN RAT
BIGNAMI, A
DAHL, D
NATURE, 1974, 252 (5478) : 55 - 56
[36] CYTOPLASMIC RIBONUCLEIC ACID CONTENT OF NEURONS IN CELL LAYERS OF VARIOUS FUNCTIONAL ZONES OF CEREBRAL CORTEX
PEVZNER, LZ
BIOCHEMISTRY-MOSCOW, 1962, 27 (04) : 559 - +
[37] STRUCTURAL AND FUNCTIONAL REARRANGEMENTS OF NEURONS AND GLIA OF THE SENSORIMOTOR CEREBRAL-CORTEX IN EXPERIMENTAL NEUROSIS
ALEXANDROVSKAYA, MM
KOLTSOVA, AV
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 1980, 30 (04) : 747 - 754
[38] Akirin2 is essential for the formation of the cerebral cortex
Bosch, Peter J.
Fuller, Leah C.
Sleeth, Carolyn M.
Weiner, Joshua A.
NEURAL DEVELOPMENT, 2016, 11
[39] THE VARIATION OF RIBOSOME QUANTITY IN GLIA AND NEURONS OF THE CEREBRAL-CORTEX DURING THE DEVELOPMENT OF SLEEP
KOGAN, AB
FELDMAN, GL
FEDORENKO, GM
GUSATINSKII, VN
DOKLADY AKADEMII NAUK SSSR, 1981, 259 (04): : 1009 - &
[40] Akirin2 is essential for the formation of the cerebral cortex
Peter J. Bosch
Leah C. Fuller
Carolyn M. Sleeth
Joshua A. Weiner
Neural Development, 11

← 1 2 3 4 5 →