A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population

被引:8
|
作者
Downie, Jonathan M. [1 ]
Tashi, Tsewang [2 ]
Lorenzo, Felipe Ramos [2 ]
Feusier, Julie Ellen [1 ]
Mir, Hyder [3 ]
Prchal, Josef T. [2 ]
Jorde, Lynn B. [1 ]
Koul, Parvaiz A. [3 ]
机构
[1] Univ Utah, Sch Med, Dept Human Genet, Salt Lake City, UT 84132 USA
[2] Univ Utah, Sch Med, Dept Internal Med, Div Hematol & Hematol Malignancies, Salt Lake City, UT USA
[3] Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar, Jammu & Kashmir, India
来源
PLOS ONE | 2016年 / 11卷 / 08期
关键词
HIGH-ALTITUDE ADAPTATION; GENETIC-EVIDENCE; PLINK;
D O I
10.1371/journal.pone.0160614
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Kashmiri population is an ethno-linguistic group that resides in the Kashmir Valley in northern India. A longstanding hypothesis is that this population derives ancestry from Jewish and/or Greek sources. There is historical and archaeological evidence of ancient Greek presence in India and Kashmir. Further, some historical accounts suggest ancient Hebrew ancestry as well. To date, it has not been determined whether signatures of Greek or Jewish admixture can be detected in the Kashmiri population. Using genome-wide genotyping and admixture detection methods, we determined there are no significant or substantial signs of Greek or Jewish admixture in modern-day Kashmiris. The ancestry of Kashmiri Tibetans was also determined, which showed signs of admixture with populations from northern India and west Eurasia. These results contribute to our understanding of the existing population structure in northern India and its surrounding geographical areas.
引用
收藏
页数:19
相关论文
共 50 条
  • [21] Genome-wide search for strabismus susceptibility loci
    Fujiwara, H
    Matsuo, T
    Sato, M
    Yamane, T
    Kitada, M
    Hasebe, S
    Ohtsuki, H
    ACTA MEDICA OKAYAMA, 2003, 57 (03) : 109 - 116
  • [22] A genome-wide search for schizophrenia susceptibility genes
    Shaw, SH
    Kelly, M
    Smith, AB
    Shields, G
    Hopkins, PJ
    Loftus, J
    Laval, SH
    Vita, A
    De Hert, M
    Cardon, LR
    Crow, TJ
    Sherrington, R
    DeLisi, LE
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1998, 81 (05): : 364 - 376
  • [23] Genome-wide search for functional noncoding RNA
    S. V. Vinogradova
    R. A. Soldatov
    A. A. Mironov
    Molecular Biology, 2013, 47 : 599 - 604
  • [24] Genome-wide search for functional noncoding RNA
    Vinogradova, S. V.
    Soldatov, R. A.
    Mironov, A. A.
    MOLECULAR BIOLOGY, 2013, 47 (04) : 599 - 604
  • [25] Neurogenetics: Genome-wide search for autism loci
    Skipper M.
    Nature Reviews Genetics, 2007, 8 (4) : 246 - 246
  • [26] Recommendations for genome-wide search for epistatic loci
    Vaitsiakhovich, Tatsiana
    Herold, Christine
    Drichel, Dmitriy
    Lacour, Andre
    Schueller, Vitalia
    Becker, Tim
    ANNALS OF HUMAN GENETICS, 2012, 76 : 432 - 433
  • [27] An Efficient Genome-Wide Multilocus Epistasis Search
    Karkkainen, Hanni P.
    Li, Zitong
    Sillanpaa, Mikko J.
    GENETICS, 2015, 201 (03) : 865 - U102
  • [28] Transcriptome changes after genome-wide admixture in invasive sculpins (Cottus)
    Czypionka, Till
    Cheng, Jie
    Pozhitkov, Alexander
    Nolte, Arne W.
    MOLECULAR ECOLOGY, 2012, 21 (19) : 4797 - 4810
  • [29] Genome-wide search in asthma and atopy patients identifies multiple loci of genome-wide significance.
    Hakonarson, H
    Halapi, E
    Bjornsdottir, US
    Upmanyu, R
    Soebech, E
    Gislason, D
    Adalsteinsdottir, AE
    Finnbogason, G
    Gislason, T
    Frigge, ML
    Kong, A
    Gulcher, JR
    Stefansson, K
    AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) : 191 - 191
  • [30] Genome-wide Association Analysis for Mixed Design Under Population Stratification in Genome-wide Association
    Won, Sungho
    Laird, Nan
    Lange, Christoph
    GENETIC EPIDEMIOLOGY, 2009, 33 (08) : 764 - 764