Comparative neurotoxic effects of root canal filling materials on rat sciatic nerve

被引：29
|
作者：
Serper, A [1 ]
Ucer, O
Onur, R
Etikan, I
机构：
[1] Hacettepe Univ, Fac Dent, Dept Endodont, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Physiol, Ankara, Turkey
[3] Hacettepe Univ, Fac Med, Dept Pharmacol, TR-06100 Ankara, Turkey
来源：
JOURNAL OF ENDODONTICS | 1998年 / 24卷 / 09期
关键词：
D O I：
10.1016/S0099-2399(98)80116-7
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The neurotoxic effects of the root canal filling materials-Endomethasone, N2 Universal, Traitement SPAD, Sealapex, and Calciobiotic Root Canal Sealer (CRCS)-were investigated on isolated rat sciatic nerves after local application. AII of the canal filling materials reversibly inhibited the compound action potential (cAP) amplitudes. N2 Universal produced a 50% inhibition in 4.2 +/- 0.2 min, Traitement SPAD, Endomethasone, and CRCS produced the same inhibition ire 6.4 +/- 0.3, 6.5 +/- 0.2, and 6.6 +/- 1.1 min, and Sealapex in 9.2 +/- 2.0 min. The inhibitory effect of Sealapex decreased fastest, and 43% recovery of cAP amplitude was observed in 60 to 70 min. The inhibitory effects of Endomethasone, CRCS, and N2 Universal were more pronounced, and 10 to 20% recovery in cAP amplitudes were observed in 2 h. The inhibitory effect of Traitement SPAD was more persistent with 4% recovery in 2.5 h.
引用
收藏
页码：592 / 594
页数：3
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