The Pentose Phosphate Pathway in Parasitic Trypanosomatids

被引:59
|
作者
Kovarova, Julie [1 ]
Barrett, Michael P. [1 ,2 ]
机构
[1] Univ Glasgow, Inst Infect Immun & Inflammat, Coll Med Vet & Life Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow G12 8TA, Lanark, Scotland
[2] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow Poly, Glasgow G12 8TA, Lanark, Scotland
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
BLOOD-STREAM FORM; 6-PHOSPHOGLUCONATE DEHYDROGENASE GENE; LEISHMANIA-MEXICANA; SACCHAROMYCES-CEREVISIAE; COMPARATIVE METABOLISM; PYRIDOXINE VITAMIN-B6; BIOLOGICAL EVALUATION; TRANSKETOLASE TKTL1; BRUCEI; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE;
D O I
10.1016/j.pt.2016.04.010
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Parasitic trypanosomatids cause important diseases. Dissecting the biochemistry of these organisms offers a means of discovering targets against which inhibitors may be designed and developed as drugs. The pentose phosphate pathway is a key route of glucose metabolism in most organisms, providing NADPH for use as a cellular reductant and various carbohydrate intermediates used in cellular metabolism. The pathway and its enzymes have been studied in Trypanosome brucei, Trypanosome cruzi, and various Leishmania species. Its functions in these parasites are becoming clear. Some enzymes of the pathway are essential to the parasites and have structural features distinguishing them from their mammalian counterparts, and this has stimulated several programs of inhibitor discovery with a view to targeting the pathway with new drugs.
引用
收藏
页码:622 / 634
页数:13
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