Inflammation and cancer: macrophage migration inhibitory factor (MIF)-the potential missing link

被引：169
|
作者：
Conroy, H. [1 ]
Mawhinney, L. [1 ]
Donnelly, S. C. [1 ]
机构：
[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Sch Med & Med Sci, Dublin 4, Ireland
来源：
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2010年 / 103卷 / 11期
关键词：
ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; FACTOR MIF; REGULATORY ROLE; COLORECTAL-CANCER; BREAST-CANCER; RHEUMATOID-ARTHRITIS; DISEASE SEVERITY; ANGIOGENESIS; HYPOXIA;
D O I：
10.1093/qjmed/hcq148
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.
引用
收藏
页码：831 / 836
页数：6
相关论文
共 50 条
  • [41] Macrophage migration inhibitory factor (MIF) - A critical neurohumoral mediator
    Petrovsky, N
    Bucala, R
    NEUROIMMUNOMODULATION: PERSPECTIVES AT THE NEW MILLENNIUM, 2000, 917 : 665 - 671
  • [42] MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury
    Unruh, Mark
    Wagner, Brent
    Hallows, Kenneth R.
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2019, 73 (03) : 429 - 431
  • [43] Expression and Function of Macrophage Migration Inhibitory Factor (MIF) in Melioidosis
    Wiersinga, W. Joost
    Calandra, Thierry
    Kager, Liesbeth M.
    van der Windt, Gerritje J. W.
    Roger, Thierry
    le Roy, Didier
    Florquin, Sandrine
    Peacock, Sharon J.
    Sweep, Fred C. G. J.
    van der Poll, Tom
    PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (02):
  • [44] Discovery of a natural antagonist of macrophage migration inhibitory factor (MIF)
    Al-Abed, Yousef
    INFLAMMATION RESEARCH, 2010, 59 : S112 - S112
  • [45] Increased levels of macrophage migration inhibitory factor (MIF) in preeclampsia
    Todros, T
    Bontempo, S
    Piccoli, E
    Ietta, F
    Romagnoli, R
    Biolcati, M
    Castellucci, M
    Paulesu, L
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2005, 123 (02) : 162 - 166
  • [46] Current developments of macrophage migration inhibitory factor (MIF) inhibitors
    Xu, Lei
    Li, Youyong
    Sun, Huiyong
    Zhen, Xuechu
    Qiao, Chunhua
    Tian, Sheng
    Hou, Tingjun
    DRUG DISCOVERY TODAY, 2013, 18 (11-12) : 592 - 600
  • [47] Macrophage migration inhibitory factor (MIF) and acute lung injury
    Baugh, J
    Donnelly, SC
    ETIOLOGY AND TREATMENT OF ACUTE LUNG INJURY: FROM BENCH TO BEDSIDE, 2001, 336 : 151 - 157
  • [48] Macrophage migration inhibitory factor (MIF) activation of rheumatoid synoviocyte
    Sampey, AV
    Hall, PH
    Bucala, R
    Morand, EF
    ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S283 - S283
  • [49] Macrophage migration inhibitory factor (MIF) interacts with pocket proteins
    Sinha, D
    Paralkar, V
    Zelenka, P
    Wistow, G
    MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 1070 - 1070
  • [50] Induction Of Macrophage Migration Inhibitory Factor (MIF) By Hydrogen Peroxide
    Russell, K. E.
    Hall, S. M.
    Simpson, K. D.
    Adcock, I. M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
12345