Interactions of HERG, ZFHX3, TBX5 and ACE gene polymorphisms associated with atrial fibrillation in Chinese Han population

Objective: To discuss how mutual effects of HERG rs1805120, ZFHX3 rs7193343, TBX5 rs3825214 and ACE rs4353 polymorphisms can affect atrial fibrillation (AF) risk in Han population of north China. Methods: The genotypes of HERG rs1805120, ZFHX3 rs7193343, TBX5 rs3825214, and ACE rs4353 polymorphisms in 90 AF patients and 90 healthy people were detected by PCR amplification and sequencing; and gene-gene interactions were analyzed with multifactor dimensionality reduction (MDR) method. Results: There existed obvious differences in genotype distributions of the four single nucleotide polymorphisms (SNPs) between the AF patients and the controls (P < 0.05). The MDR analysis results indicated that the rs1805120-rs7193343-rs3825214-rs4353 model was the optimal model among all the interaction models formed by the four SNPs (OR =8.1850, 95% CI =3.912817.1220, P < 0.0001). Conclusions: It is possible that interactions of HERG rs1805120, ZFHX3 rs7193343, TBX5 rs3825214, and ACE rs4353 polymorphisms can confer increased risk of AF.