Focal adhesions: structure and dynamics

被引：274
|
作者：
Petit, V [1 ]
Thiery, JP [1 ]
机构：
[1] Inst Curie, CNRS, UMR 144, Div Res, F-75248 Paris 05, France
来源：
BIOLOGY OF THE CELL | 2000年 / 92卷 / 07期
关键词：
focal adhesion; integrins; extracellular matrix; Rho;
D O I：
10.1016/S0248-4900(00)01101-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：477 / 494
页数：18
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