Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages

被引：3

作者：

Krutetskaya, Z., I ^{[1
]}

Milenina, L. S. ^{[1
]}

Antonov, V. G. ^{[1
]}

Nozdrachev, A. D. ^{[1
,2
]}

机构：

[1] St Petersburg State Univ, St Petersburg, Russia

[2] Russian Acad Sci, Inst Physiol, St Petersburg, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2019年 / 488卷 / 01期

关键词：

PHARMACOLOGY;

D O I：

10.1134/S1607672919050041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist-tricyclic antidepressant amitriptyline-significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.

引用

页码：307 / 310

页数：4

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