Fecal Microbiota Transplantation for Chronic Liver Diseases: Current Understanding and Future Direction

被引：31

作者：

Lechner, Sarah ^{[1
]}

Yee, Matthew ^{[1
,2
]}

Limketkai, Berkeley N. ^{[3
]}

Pham, Edward A. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

[3] Univ Calif Los Angeles, Div Digest Dis, Los Angeles, CA USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2020年 / 65卷 / 03期

关键词：

Fecal microbiota transplantation (FMT); Chronic liver diseases; Alcoholic liver disease (ALD); Nonalcoholic liver disease (NAFLD); Nonalcoholic hepatitis (NASH); Bile acids; PRIMARY SCLEROSING CHOLANGITIS; SEVERE ALCOHOLIC HEPATITIS; BACTERIAL TRANSLOCATION; INTESTINAL MICROBIOTA; CLINICAL-TRIAL; DYSBIOSIS; RESISTANCE; CLEARANCE; INFECTION; MICE;

D O I：

10.1007/s10620-020-06100-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic liver disease is a major cause of morbidity and mortality worldwide. Even though effective treatments are now available for most chronic viral hepatitis, treatment options for other causes of chronic liver disease remain inadequate. Recent research has revealed a previously unappreciated role that the human intestinal microbiome plays in mediating the development and progression of chronic liver diseases. The recent remarkable success of fecal microbiota transplantation (FMT) in treating Clostridioides difficile demonstrates that the intestinal microbiota can be manipulated to obtain favorable therapeutic benefits and that FMT may become an important component of a total therapeutic approach to effectively treat hepatic disorders.

引用

页码：897 / 905

页数：9

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