Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents

被引：26

作者：

Ellanki, Amarender Reddy ^{[2
,5
]}

Islam, Aminul ^{[2
]}

Rama, Veera Swamy ^{[2
]}

Pulipati, Ranga Prasad ^{[2
]}

Rambabu, D. ^{[1
,3
]}

Krishna, G. Rama ^{[4
]}

Reddy, C. Malla ^{[4
]}

Mukkanti, K. ^{[5
]}

Vanaja, G. R. ^{[6
]}

Kalle, Arunasree M. ^{[6
]}

Kumar, K. Shiva ^{[1
]}

Pal, Manojit ^{[1
]}

机构：

[1] Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, Chem Technol Dev Ctr, Hyderabad 500049, Andhra Pradesh, India

[3] KL Univ, Dept Chem, Guntur 522502, Andhra Pradesh, India

[4] Indian Inst Sci Educ & Res, Dept Chem Sci, Kolkata 741252, W Bengal, India

[5] JNT Univ, Inst Sci & Technol, Div Chem, Hyderabad 500072, Andhra Pradesh, India

[6] Univ Hyderabad, Sch Life Sci, Dept Anim Sci, Hyderabad 500046, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 10期

关键词：

Click chemistry; Azide; Alkyne; Quinoline; Cancer; CLICK CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; EFFICIENT;

D O I：

10.1016/j.bmcl.2012.03.091

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et3N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3455 / 3459

页数：5

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